Cooperative modulation of mineral growth by prismatic-associated Asprich sequences and Mg(II)

Il Won Kim, Sebastiano Collino, John Spencer Evans

    Research output: Contribution to journalArticlepeer-review


    Cooperative effects of magnesium ions and acidic polypeptides originating from a family of proteins known as Asprich (mollusk Atrina rigida) were studied. In our previous studies, these two acidic polypeptides were found to be effective in controlling the morphology of the calcium carbonate mineral, the main inorganic constituent of prismatic layer of the mollusk shell. Since these Asprich sequences are believed to contain a putative magnesium binding domain, the morphology-controlling effects were further investigated with the addition of magnesium ions. The mineral morphology was dramatically changed by the combined influence of each polypeptides and the magnesium ions, substantiating the recognized importance of magnesium in the formation of calcium carbonate-based biominerals.

    Original languageEnglish (US)
    Pages (from-to)3949-3958
    Number of pages10
    JournalInternational journal of molecular sciences
    Issue number3
    StatePublished - Mar 2012


    • Biomineralization
    • Calcium carbonate
    • Magnesium
    • Mollusk
    • Polypeptide

    ASJC Scopus subject areas

    • Catalysis
    • Molecular Biology
    • Spectroscopy
    • Computer Science Applications
    • Physical and Theoretical Chemistry
    • Organic Chemistry
    • Inorganic Chemistry


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