Cooperativity between cell contractility and adhesion

Igor L. Novak; Boris M. Slepchenko; Alex Mogilner; Leslie M. Loew

doi:10.1103/PhysRevLett.93.268109

Cooperativity between cell contractility and adhesion

Igor L. Novak, Boris M. Slepchenko, Alex Mogilner, Leslie M. Loew

Research output: Contribution to journal › Article › peer-review

Abstract

A latest model is introduce to explain why the focal adhesions tend to high-curvature regions at the cell periphery. The model predicts that the focal adhesions propagate by treadmilling with a velocity proportional to the integrin diffusion coefficient. Focal adhesion not only provide the physical link between the cytoskeleton and the extracellular matrix (ECM) but also serve as a cell's tactile device probing the rigidity of the external environment. It was observed that focal adhesion relocate to the cell periphery and concentrate at the the regions with the highest boundary carvature.

Original language	English (US)
Article number	268109
Journal	Physical Review Letters
Volume	93
Issue number	26 I
DOIs	https://doi.org/10.1103/PhysRevLett.93.268109
State	Published - Dec 31 2004

ASJC Scopus subject areas

Physics and Astronomy(all)

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abstract = "A latest model is introduce to explain why the focal adhesions tend to high-curvature regions at the cell periphery. The model predicts that the focal adhesions propagate by treadmilling with a velocity proportional to the integrin diffusion coefficient. Focal adhesion not only provide the physical link between the cytoskeleton and the extracellular matrix (ECM) but also serve as a cell's tactile device probing the rigidity of the external environment. It was observed that focal adhesion relocate to the cell periphery and concentrate at the the regions with the highest boundary carvature.",

author = "Novak, {Igor L.} and Slepchenko, {Boris M.} and Alex Mogilner and Loew, {Leslie M.}",

note = "Funding Information: We thank B. Geiger, A. R. Horwitz, I. Moraru, J. E. Pearson, and M. A. Schwartz for helpful discussions and suggestions. This work was supported by NIH Grants No. U54 GM64346 and No. P41 RR13186.",

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