Cooperativity between cell contractility and adhesion

Igor L. Novak, Boris M. Slepchenko, Alex Mogilner, Leslie M. Loew

Research output: Contribution to journalArticlepeer-review


A latest model is introduce to explain why the focal adhesions tend to high-curvature regions at the cell periphery. The model predicts that the focal adhesions propagate by treadmilling with a velocity proportional to the integrin diffusion coefficient. Focal adhesion not only provide the physical link between the cytoskeleton and the extracellular matrix (ECM) but also serve as a cell's tactile device probing the rigidity of the external environment. It was observed that focal adhesion relocate to the cell periphery and concentrate at the the regions with the highest boundary carvature.

Original languageEnglish (US)
Article number268109
JournalPhysical Review Letters
Issue number26 I
StatePublished - Dec 31 2004

ASJC Scopus subject areas

  • General Physics and Astronomy


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