TY - JOUR
T1 - Coordinating different representations in the hippocampus
AU - Kelemen, Eduard
AU - Fenton, André A.
N1 - Funding Information:
This material is based upon work supported by the National Science Foundation under Grant Number ( IOS-1146822 ), National Institute of Mental Health grant R01MH084038 , Deutsche Forschungsgemeinschaft ( TR-SFB 654 ), German Federal Ministry of Education and Research (BMBF) grant to the German Center for Diabetes Research (DZD e.V.; 01GI0925 ), the project “ National Institute of Mental Health (NIMH-CZ) ” grant ED2.1.00/03.0078 , the European Regional Development Fund, and Czech Science Foundation (GAČR grant 14-03627S ). Institutional support for the Institute of Physiology, CAS was provided by RVO: 67985823.
Publisher Copyright:
© 2016 Elsevier Inc..
PY - 2016/3/1
Y1 - 2016/3/1
N2 - The processes that organize different thoughts and memories, allowing the separation of currently relevant and irrelevant information, are collectively known as cognitive control. The neuronal mechanisms of these processes can be investigated by place cell ensemble recordings during behaviors and environmental manipulations that present cognitive control challenges to selectively represent one of multiple possible alternative estimates of location. We review place cell studies that investigate responses to manipulations that dissociate the environment into two or more spatial frames of locations, often times to test notions of pattern separation. Manipulations, such as continuously rotating the recording chamber reveal that the ensemble discharge in hippocampus self-organizes into multiple, transiently-organized representations of space, each defined by the subset of coactive cells. Ensemble discharge in the hippocampus alternates between separate representations of frame-specific positions on timescales from 25 ms to several seconds. The dynamic, functional grouping of discharge into transiently co-active subsets of cells is predicted by the animal's changing behavioral needs. In addition to identifying neural correlates of cognitive control in hippocampus, these observations demonstrate that the separation of neuronal activity into distinctive representations depends on ongoing cognitive demands and that what can appear as noise, deviations from receptive field tuning, can substantially be the result of these internal knowledge-guided fluctuations. These findings inspire a new perspective that should be taken into account when investigating pattern separation - a perspective that emphasizes changes in hippocampal neural discharge that are happening on a short timescale and does not assume that patterns of neural discharge are steady and stationary across the several minutes of the recordings.
AB - The processes that organize different thoughts and memories, allowing the separation of currently relevant and irrelevant information, are collectively known as cognitive control. The neuronal mechanisms of these processes can be investigated by place cell ensemble recordings during behaviors and environmental manipulations that present cognitive control challenges to selectively represent one of multiple possible alternative estimates of location. We review place cell studies that investigate responses to manipulations that dissociate the environment into two or more spatial frames of locations, often times to test notions of pattern separation. Manipulations, such as continuously rotating the recording chamber reveal that the ensemble discharge in hippocampus self-organizes into multiple, transiently-organized representations of space, each defined by the subset of coactive cells. Ensemble discharge in the hippocampus alternates between separate representations of frame-specific positions on timescales from 25 ms to several seconds. The dynamic, functional grouping of discharge into transiently co-active subsets of cells is predicted by the animal's changing behavioral needs. In addition to identifying neural correlates of cognitive control in hippocampus, these observations demonstrate that the separation of neuronal activity into distinctive representations depends on ongoing cognitive demands and that what can appear as noise, deviations from receptive field tuning, can substantially be the result of these internal knowledge-guided fluctuations. These findings inspire a new perspective that should be taken into account when investigating pattern separation - a perspective that emphasizes changes in hippocampal neural discharge that are happening on a short timescale and does not assume that patterns of neural discharge are steady and stationary across the several minutes of the recordings.
KW - Cognitive control
KW - Dynamic functional grouping
KW - Hippocampus
KW - Multiple representations
KW - Overdispersion
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U2 - 10.1016/j.nlm.2015.12.011
DO - 10.1016/j.nlm.2015.12.011
M3 - Review article
C2 - 26748023
AN - SCOPUS:84969301103
SN - 1074-7427
VL - 129
SP - 50
EP - 59
JO - Neurobiology of Learning and Memory
JF - Neurobiology of Learning and Memory
ER -