Coordinating Synaptic Signaling with CRMP2

Harrison Stratton, Lisa Boinon, Aubin Moutal, Rajesh Khanna

Research output: Contribution to journalComment/debatepeer-review


Synaptic transmission is a complex process, dysregulation of which underlies several neurological conditions. Collapsin response mediator protein 2 (CRMP2) is a microtubule associated protein expressed ubiquitously in the central nervous system. Identified initially in the context of Semaphorin 3A (Collapsin) induced growth cone collapse, more recent findings revealed the involvement of CRMP2 in ion channel trafficking, kinesin-dependent axonal transport and maintenance of intracellular calcium homeostasis. CRMP2 is a synaptic protein, expressed at pre- and post-synaptic sites. Interactions with proteins such as N-methyl-D-aspartate receptors, syntaxin1A as well as voltage-gated calcium and sodium channels, suggest that CRMP2 may control both the electrical and chemical components of synaptic transmission. This short review will outline the known synaptic interactions of CRMP2 and illustrate its role in synaptic transmission, thereby introducing CRMP2 as a prospective target for the pathophysiological modulation of aberrant synaptic activity.

Original languageEnglish (US)
Article number105759
JournalInternational Journal of Biochemistry and Cell Biology
StatePublished - Jul 2020


  • CaV2.2
  • Collapsin-response-mediator-protein 2
  • NaV1.7
  • Synaptic signaling

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology


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