Copper- and ligand-free Sonogashira reaction catalyzed by Pd(0) nanoparticles at ambient conditions under ultrasound irradiation

Atul R. Gholap, K. Venkatesan, Renu Pasricha, Thomas Daniel, Rajgopal J. Lahoti, Kumar V. Srinivasan

Research output: Contribution to journalArticlepeer-review

Abstract

The Sonogashira reaction proceeds at ambient temperature (30°C) in acetone or room-temperature ionic liquid, 1,3-di-n-butylimidazolium tetrafluoroborate ([bbim]BF4), as solvent under ultrasound irradiation to give enhanced reaction rates, excellent chemoselectivity, and high yields in the absence of a copper cocatalyst and a phosphine ligand. TEM analysis showed the formation of stable, crystalline, and polydispersed Pd(0) nanoparticles as catalyst for the reaction.

Original languageEnglish (US)
Pages (from-to)4869-4872
Number of pages4
JournalJournal of Organic Chemistry
Volume70
Issue number12
DOIs
StatePublished - Jun 12 2005

ASJC Scopus subject areas

  • Organic Chemistry

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