Correction to: Helminth colonization is associated with increased diversity of the gut microbiota (PLoS Neglected Tropical Diseases)

Soo Ching Lee, Mei San Tang, Yvonne A.L. Lim, Seow Huey Choy, Zachary D. Kurtz, Laura M. Cox, Uma Mahesh Gundra, Ilseung Cho, Richard Bonneau, Martin J. Blaser, Kek Heng Chua, P’Ng Loke

Research output: Contribution to journalComment/debatepeer-review

Abstract

Explanation of the Correction provided by the authors: The authors were recently brought to attention about inconsistencies in the color-coding of helminth positive vs. helminth negative individuals between panels in Figs 1 and 2 of this publication [1]. During the process of responding to these queries, we identified mislabeling in the metadata for the analysis of the alpha diversity metric Observed Operational Taxonomic Units (OTUs), where helminth positive and helminth negative individuals were not matched to the correct values of Observed OTUs. The corrected values along with the associated helminth colonization status are presented here. There is no association between Observed OTUs and age using the corrected values, as described in the original publication (Fig 1A). However, we found that the differences in Observed OTUs between helminth positive and helminth negative individuals were statistically not significant (p = 0.73, Fig 2D, graph 1), which was different from our original report. While there was no mislabeling in the calculations of the alpha diversity metrics Faith’s Phylogenetic Diversity and Shannon index, we have re-visualized the values of these two alpha diversity metrics in similar boxplot formats for comparison. The Phylogenetic Diversity of the gut microbiota between helminth positive and helminth negative individuals was significantly different (p = 0.041, Fig 2D, graph 2), while the Shannon index of the gut microbiota between helminth positive and helminth negative individuals was statistically not significant (p = 0.303, Fig 2D, graph 3), as reported in the original publication. Values for each alpha diversity metric, along with the associated helminth status, are available in S1 File. The original publication has not been corrected online.

Original languageEnglish (US)
Article numbere0009325
JournalPLoS neglected tropical diseases
Volume8
Issue number5
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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