Correlates of adherence to varenicline among HIV+ smokers

Donna Shelley, Tuo Yen Tseng, Mirelis Gonzalez, Paul Krebs, Selena Wong, Robert Furberg, Scott Sherman, Antoinette Schoenthaler, Anthony Urbina, Charles M. Cleland

Research output: Contribution to journalArticlepeer-review


Introduction: Low rates of adherence to smoking cessation pharmacotherapy may limit the effectiveness of treatment. However, few studies have examined adherence in smoking cessation trials thus, there is a limited understanding of factors that influence adherence behaviors. This brief report analyzes correlates of adherence to varenicline among people living with HIV/AIDS. Methods: Study participants were recruited from three HIV care centers in New York City and enrolled in a three-arm randomized controlled pilot study in which all subjects received varenicline. At the 1-month study visit, there were no significant differences in adherence by study condition, therefore we combined treatment arms to examine correlates of adherence (n = 127). We used pill counts to assess varenicline adherence, defined as taking at least 80% of the prescribed dose. We conducted a multivariate path analysis to assess factors proposed by the informationmotivation-behavioral skills model to predict adherence. Results: Only 56% of smokers were at least 80% adherent to varenicline at 1 month. Adherencerelated information, self-efficacy, a college degree, and non-Hispanic white race/ethnicity were associated with increased varenicline adherence. In path analysis, information and motivation were associated with increased adherence self-efficacy, and adherence self-efficacy was associated with increased adherence, but with marginal significance. These associations with adherence were no longer significant after controlling for race/ethnicity and education. Conclusions: Further exploration of the role of a modifiable correlates of adherence, such as adherencerelated information, motivation and self-efficacy is warranted. Interventions are needed that can address disparities in these and other psychosocial factors that may mediate poor medication adherence.

Original languageEnglish (US)
Pages (from-to)968-974
Number of pages7
JournalNicotine and Tobacco Research
Issue number8
StatePublished - Apr 22 2015

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


Dive into the research topics of 'Correlates of adherence to varenicline among HIV+ smokers'. Together they form a unique fingerprint.

Cite this