Cortical Variability in the Sensory-Evoked Response in Autism

Sarah M. Haigh; David J. Heeger; Ilan Dinstein; Nancy Minshew; Marlene Behrmann

doi:10.1007/s10803-014-2276-6

Cortical Variability in the Sensory-Evoked Response in Autism

Sarah M. Haigh, David J. Heeger, Ilan Dinstein, Nancy Minshew, Marlene Behrmann

Research output: Contribution to journal › Article › peer-review

Abstract

Previous findings have shown that individuals with autism spectrum disorder (ASD) evince greater intra-individual variability (IIV) in their sensory-evoked fMRI responses compared to typical control participants. We explore the robustness of this finding with a new sample of high-functioning adults with autism. Participants were presented with visual, somatosensory and auditory stimuli in the scanner whilst they completed a one-back task. While ASD and control participants were statistically indistinguishable with respect to behavioral responses, the new ASD group exhibited greater IIV relative to controls. We also show that the IIV was equivalent across hemispheres and remained stable over the duration of the experiment. This suggests that greater cortical IIV may be a replicable characteristic of sensory systems in autism.

Original language	English (US)
Pages (from-to)	1176-1190
Number of pages	15
Journal	Journal of Autism and Developmental Disorders
Volume	45
Issue number	5
DOIs	https://doi.org/10.1007/s10803-014-2276-6
State	Published - May 1 2015

Keywords

Autism
Sensory-evoked
Variability
fMRI

ASJC Scopus subject areas

Developmental and Educational Psychology

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10.1007/s10803-014-2276-6

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title = "Cortical Variability in the Sensory-Evoked Response in Autism",

abstract = "Previous findings have shown that individuals with autism spectrum disorder (ASD) evince greater intra-individual variability (IIV) in their sensory-evoked fMRI responses compared to typical control participants. We explore the robustness of this finding with a new sample of high-functioning adults with autism. Participants were presented with visual, somatosensory and auditory stimuli in the scanner whilst they completed a one-back task. While ASD and control participants were statistically indistinguishable with respect to behavioral responses, the new ASD group exhibited greater IIV relative to controls. We also show that the IIV was equivalent across hemispheres and remained stable over the duration of the experiment. This suggests that greater cortical IIV may be a replicable characteristic of sensory systems in autism.",

keywords = "Autism, Sensory-evoked, Variability, fMRI",

author = "Haigh, {Sarah M.} and Heeger, {David J.} and Ilan Dinstein and Nancy Minshew and Marlene Behrmann",

note = "Funding Information: The research described here was supported by a Grant from the Simons Foundation Autism Research Initiative (177638) to DH and MB, and a NIH/NICHD Grant (HD055748) to NJM. The authors thank Ryan Egan for helping with participant recruitment and fMRI testing. We also thank the staff at the Center for Excellence in Autism Research at the University of Pittsburgh for recruitment and assessment of participants. Publisher Copyright: {\textcopyright} 2014, Springer Science+Business Media New York.",

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doi = "10.1007/s10803-014-2276-6",

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AU - Haigh, Sarah M.

AU - Heeger, David J.

AU - Dinstein, Ilan

AU - Minshew, Nancy

AU - Behrmann, Marlene

N1 - Funding Information: The research described here was supported by a Grant from the Simons Foundation Autism Research Initiative (177638) to DH and MB, and a NIH/NICHD Grant (HD055748) to NJM. The authors thank Ryan Egan for helping with participant recruitment and fMRI testing. We also thank the staff at the Center for Excellence in Autism Research at the University of Pittsburgh for recruitment and assessment of participants. Publisher Copyright: © 2014, Springer Science+Business Media New York.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Previous findings have shown that individuals with autism spectrum disorder (ASD) evince greater intra-individual variability (IIV) in their sensory-evoked fMRI responses compared to typical control participants. We explore the robustness of this finding with a new sample of high-functioning adults with autism. Participants were presented with visual, somatosensory and auditory stimuli in the scanner whilst they completed a one-back task. While ASD and control participants were statistically indistinguishable with respect to behavioral responses, the new ASD group exhibited greater IIV relative to controls. We also show that the IIV was equivalent across hemispheres and remained stable over the duration of the experiment. This suggests that greater cortical IIV may be a replicable characteristic of sensory systems in autism.

AB - Previous findings have shown that individuals with autism spectrum disorder (ASD) evince greater intra-individual variability (IIV) in their sensory-evoked fMRI responses compared to typical control participants. We explore the robustness of this finding with a new sample of high-functioning adults with autism. Participants were presented with visual, somatosensory and auditory stimuli in the scanner whilst they completed a one-back task. While ASD and control participants were statistically indistinguishable with respect to behavioral responses, the new ASD group exhibited greater IIV relative to controls. We also show that the IIV was equivalent across hemispheres and remained stable over the duration of the experiment. This suggests that greater cortical IIV may be a replicable characteristic of sensory systems in autism.

KW - Autism

KW - Sensory-evoked

KW - Variability

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Cortical Variability in the Sensory-Evoked Response in Autism

Abstract

Keywords

ASJC Scopus subject areas

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