Coupling across a DNA helical turn yields a hybrid DNA/organic catenane doubly tailed with functional termini

Yu Liu; Akinori Kuzuya; Ruojie Sha; Johan Guillaume; Risheng Wang; James W. Canary; Nadrian C. Seeman

doi:10.1021/ja8041096

Coupling across a DNA helical turn yields a hybrid DNA/organic catenane doubly tailed with functional termini

Yu Liu, Akinori Kuzuya, Ruojie Sha, Johan Guillaume, Risheng Wang, James W. Canary, Nadrian C. Seeman

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. The product, a doubly tailed catenane, contains 5′- and 3′-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.

Original language	English (US)
Pages (from-to)	10882-10883
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	130
Issue number	33
DOIs	https://doi.org/10.1021/ja8041096
State	Published - Aug 20 2008

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja8041096

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abstract = "We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. The product, a doubly tailed catenane, contains 5′- and 3′-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.",

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AU - Liu, Yu

AU - Kuzuya, Akinori

AU - Sha, Ruojie

AU - Guillaume, Johan

AU - Wang, Risheng

AU - Canary, James W.

AU - Seeman, Nadrian C.

PY - 2008/8/20

Y1 - 2008/8/20

N2 - We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. The product, a doubly tailed catenane, contains 5′- and 3′-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.

AB - We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. The product, a doubly tailed catenane, contains 5′- and 3′-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.

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Coupling across a DNA helical turn yields a hybrid DNA/organic catenane doubly tailed with functional termini

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