TY - JOUR
T1 - Crawling, waving, inch worming, dilating, and pivoting mechanics of migrating cells
T2 - Lessons from Ken Jacobson
AU - Mogilner, Alex
AU - Savinov, Mariya
N1 - Publisher Copyright:
© 2023 Biophysical Society
PY - 2023/9/19
Y1 - 2023/9/19
N2 - Research on the locomotion of single cells on hard, flat surfaces brought insight into the mechanisms of leading-edge protrusion, spatially graded adhesion, front-rear coordination, and how intracellular and traction forces are harnessed to execute various maneuvers. Here, we highlight how, by studying a variety of cell types, shapes, and movements, Ken Jacobson and his collaborators made several discoveries that triggered the mechanistic understanding of cell motility. We then review the recent advancements and current perspectives in this field.
AB - Research on the locomotion of single cells on hard, flat surfaces brought insight into the mechanisms of leading-edge protrusion, spatially graded adhesion, front-rear coordination, and how intracellular and traction forces are harnessed to execute various maneuvers. Here, we highlight how, by studying a variety of cell types, shapes, and movements, Ken Jacobson and his collaborators made several discoveries that triggered the mechanistic understanding of cell motility. We then review the recent advancements and current perspectives in this field.
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U2 - 10.1016/j.bpj.2023.03.023
DO - 10.1016/j.bpj.2023.03.023
M3 - Review article
C2 - 36934300
AN - SCOPUS:85151288855
SN - 0006-3495
VL - 122
SP - 3551
EP - 3559
JO - Biophysical journal
JF - Biophysical journal
IS - 18
ER -