Critical examination of Fe8 as a contrast agent for magnetic resonance imaging

Steven Isaacman; Rajeev Kumar; Enrique Del Barco; Andrew D. Kent; James W. Canary; Alexej Jerschow

doi:10.1016/j.poly.2005.03.138

Critical examination of Fe₈ as a contrast agent for magnetic resonance imaging

Steven Isaacman, Rajeev Kumar, Enrique Del Barco, Andrew D. Kent, James W. Canary, Alexej Jerschow

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The compound Fe₈ (C₃₆H₁₂₀O ₂₃N₁₈Fe₈Br₈) was examined for its potential as a contrast agent for magnetic resonance imaging. The compound was prepared, isolated, and shown to exhibit superparamagnetism (S = 10). The structure of Fe₈ in aqueous solution was probed by several NMR techniques. Relaxivity of aqueous solutions of Fe₈ as well as that of comparison compounds FeCl₃, FeCl₃(tacn) (tacn = 1,4,7-triazacyclononane), and Gd(DTPA) (DTPA = diethylenetriamine pentaacetic acid) were determined by T₁ and T₂ inversion recovery and CPMG sequences. In contrast to a previous report, the relaxivity of Fe ₈ solutions was found to be weak compared to Gd(DTPA). However, an interesting dependence upon pH was observed. The influence of environmental factors on relaxivity is of interest in the burgeoning field of molecular imaging.

Original language	English (US)
Pages (from-to)	2691-2694
Number of pages	4
Journal	Polyhedron
Volume	24
Issue number	16-17
DOIs	https://doi.org/10.1016/j.poly.2005.03.138
State	Published - Nov 17 2005

Keywords

Contrast agent
Magnetic resonance imaging
Relaxation
Single-molecule magnet
Superparamagnet

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

Access to Document

10.1016/j.poly.2005.03.138

Cite this

@article{a094b40f53d44e6b9359133de053d696,

title = "Critical examination of Fe8 as a contrast agent for magnetic resonance imaging",

abstract = "The compound Fe8 (C36H120O 23N18Fe8Br8) was examined for its potential as a contrast agent for magnetic resonance imaging. The compound was prepared, isolated, and shown to exhibit superparamagnetism (S = 10). The structure of Fe8 in aqueous solution was probed by several NMR techniques. Relaxivity of aqueous solutions of Fe8 as well as that of comparison compounds FeCl3, FeCl3(tacn) (tacn = 1,4,7-triazacyclononane), and Gd(DTPA) (DTPA = diethylenetriamine pentaacetic acid) were determined by T1 and T2 inversion recovery and CPMG sequences. In contrast to a previous report, the relaxivity of Fe 8 solutions was found to be weak compared to Gd(DTPA). However, an interesting dependence upon pH was observed. The influence of environmental factors on relaxivity is of interest in the burgeoning field of molecular imaging.",

keywords = "Contrast agent, Magnetic resonance imaging, Relaxation, Single-molecule magnet, Superparamagnet",

author = "Steven Isaacman and Rajeev Kumar and Barco, {Enrique Del} and Kent, {Andrew D.} and Canary, {James W.} and Alexej Jerschow",

note = "Funding Information: This work was supported by the National Science Foundation, Grant #NSF-DMR-0103290, and the NYU Whitehead Fellowship for Junior Faculty in the Biomedical and Biological Sciences. New York University is a member institution of the New York Structural Biology Center supported by NIH Grant 1P41 GM66354. NYU{\textquoteright}s NMR facilities were supported by a NSF grant MRI-0116222. We acknowledge Dr. Chin Lin and the Molecular Imaging and Contrast Agent Working Group at NYU.",

year = "2005",

month = nov,

day = "17",

doi = "10.1016/j.poly.2005.03.138",

language = "English (US)",

volume = "24",

pages = "2691--2694",

journal = "Polyhedron",

issn = "0277-5387",

publisher = "Elsevier Limited",

number = "16-17",

}

TY - JOUR

T1 - Critical examination of Fe8 as a contrast agent for magnetic resonance imaging

AU - Isaacman, Steven

AU - Kumar, Rajeev

AU - Barco, Enrique Del

AU - Kent, Andrew D.

AU - Canary, James W.

AU - Jerschow, Alexej

N1 - Funding Information: This work was supported by the National Science Foundation, Grant #NSF-DMR-0103290, and the NYU Whitehead Fellowship for Junior Faculty in the Biomedical and Biological Sciences. New York University is a member institution of the New York Structural Biology Center supported by NIH Grant 1P41 GM66354. NYU’s NMR facilities were supported by a NSF grant MRI-0116222. We acknowledge Dr. Chin Lin and the Molecular Imaging and Contrast Agent Working Group at NYU.

PY - 2005/11/17

Y1 - 2005/11/17

N2 - The compound Fe8 (C36H120O 23N18Fe8Br8) was examined for its potential as a contrast agent for magnetic resonance imaging. The compound was prepared, isolated, and shown to exhibit superparamagnetism (S = 10). The structure of Fe8 in aqueous solution was probed by several NMR techniques. Relaxivity of aqueous solutions of Fe8 as well as that of comparison compounds FeCl3, FeCl3(tacn) (tacn = 1,4,7-triazacyclononane), and Gd(DTPA) (DTPA = diethylenetriamine pentaacetic acid) were determined by T1 and T2 inversion recovery and CPMG sequences. In contrast to a previous report, the relaxivity of Fe 8 solutions was found to be weak compared to Gd(DTPA). However, an interesting dependence upon pH was observed. The influence of environmental factors on relaxivity is of interest in the burgeoning field of molecular imaging.

AB - The compound Fe8 (C36H120O 23N18Fe8Br8) was examined for its potential as a contrast agent for magnetic resonance imaging. The compound was prepared, isolated, and shown to exhibit superparamagnetism (S = 10). The structure of Fe8 in aqueous solution was probed by several NMR techniques. Relaxivity of aqueous solutions of Fe8 as well as that of comparison compounds FeCl3, FeCl3(tacn) (tacn = 1,4,7-triazacyclononane), and Gd(DTPA) (DTPA = diethylenetriamine pentaacetic acid) were determined by T1 and T2 inversion recovery and CPMG sequences. In contrast to a previous report, the relaxivity of Fe 8 solutions was found to be weak compared to Gd(DTPA). However, an interesting dependence upon pH was observed. The influence of environmental factors on relaxivity is of interest in the burgeoning field of molecular imaging.

KW - Contrast agent

KW - Magnetic resonance imaging

KW - Relaxation

KW - Single-molecule magnet

KW - Superparamagnet

UR - http://www.scopus.com/inward/record.url?scp=27644489103&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27644489103&partnerID=8YFLogxK

U2 - 10.1016/j.poly.2005.03.138

DO - 10.1016/j.poly.2005.03.138

M3 - Article

AN - SCOPUS:27644489103

SN - 0277-5387

VL - 24

SP - 2691

EP - 2694

JO - Polyhedron

JF - Polyhedron

IS - 16-17

ER -