Cross-dressing proteins by olefin metathesis

Kent Kirshenbaum; Paramjit S. Arora

doi:10.1038/nchembio0908-527

Cross-dressing proteins by olefin metathesis

Kent Kirshenbaum, Paramjit S. Arora

Chemistry

Research output: Contribution to journal › Short survey › peer-review

Abstract

Chemists have established numerous methods for performing protein conjugations, but metathesis catalysts have largely remained absent from this toolkit. Evidence that proteins bearing allylsulfides undergo cross-metathesis with chosen alkenes in aqueous conditions will allow chemists to harness the power of metathesis catalysts for modifying biomolecules and other water-soluble compounds.

Original language	English (US)
Pages (from-to)	527-528
Number of pages	2
Journal	Nature Chemical Biology
Volume	4
Issue number	9
DOIs	https://doi.org/10.1038/nchembio0908-527
State	Published - Sep 2008

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/nchembio0908-527

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abstract = "Chemists have established numerous methods for performing protein conjugations, but metathesis catalysts have largely remained absent from this toolkit. Evidence that proteins bearing allylsulfides undergo cross-metathesis with chosen alkenes in aqueous conditions will allow chemists to harness the power of metathesis catalysts for modifying biomolecules and other water-soluble compounds.",

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AB - Chemists have established numerous methods for performing protein conjugations, but metathesis catalysts have largely remained absent from this toolkit. Evidence that proteins bearing allylsulfides undergo cross-metathesis with chosen alkenes in aqueous conditions will allow chemists to harness the power of metathesis catalysts for modifying biomolecules and other water-soluble compounds.

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Cross-dressing proteins by olefin metathesis

Abstract

ASJC Scopus subject areas

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