Cross-regulatory interactions among pair-rule genes in Drosophila

K. Harding, C. Rushlow, H. J. Doyle, T. Hoey, M. Levine

Research output: Contribution to journalArticlepeer-review


The pair-rule genes of Drosophila are required for the subdivision of the developing embryo into a repeating series of homologous body segments. One of the pair-rule genes, even-skipped (eve), appears to be particularly important for the overall segmentation pattern since eve - embryos lack all segmental subdivisions in the middle body region. On the basis of homeo box cross-homology we have isolated a gene, S72, which probably corresponds to eve. In embryo tissue sections S72 transcripts show a periodic distribution pattern. The eve - phenotype appears to involve altered patterns of fushi tarazu and engrailed expression. These and other findings suggest that pair-rule gene expression might involve hierarchical cross-regulatory interactions.

Original languageEnglish (US)
Pages (from-to)953-959
Number of pages7
Issue number4767
StatePublished - 1986

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Cross-regulatory interactions among pair-rule genes in Drosophila'. Together they form a unique fingerprint.

Cite this