TY - GEN
T1 - CRYOPRESERVATION OF 3D TUMOR MODELS IN A PAPER PLATFORM
AU - Samara, Bisan
AU - Deliorman, Muhammedin
AU - Sukumar, Pavithra
AU - Qasaimeh, Mohammad A.
N1 - Funding Information:
This work is supported by NYU Abu Dhabi.
Publisher Copyright:
© 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
PY - 2021
Y1 - 2021
N2 - The ability to investigate three dimensional (3D) tumor models within their microenvironment offers great potential for understanding fundamental mechanisms governing tumor responses to drug treatments. It also provides opportunities to develop a number of emerging therapeutic applications. Selectively growing cell aggregates on predefined microspots is one of the key requirements when forming 3D tumor models for undertaking such studies. In our work, we engineered highly localized hydrophilic microspots on a paper substrate for high throughput 3D cell aggregation. Building on our previous work, we also efficiently cryopreserved the formed 3D tumor models and showed, after thaw, the compatibility of the paper platform for on-demand drug testing on the tumor models.
AB - The ability to investigate three dimensional (3D) tumor models within their microenvironment offers great potential for understanding fundamental mechanisms governing tumor responses to drug treatments. It also provides opportunities to develop a number of emerging therapeutic applications. Selectively growing cell aggregates on predefined microspots is one of the key requirements when forming 3D tumor models for undertaking such studies. In our work, we engineered highly localized hydrophilic microspots on a paper substrate for high throughput 3D cell aggregation. Building on our previous work, we also efficiently cryopreserved the formed 3D tumor models and showed, after thaw, the compatibility of the paper platform for on-demand drug testing on the tumor models.
KW - 3D tumor models
KW - Cryopreservation
KW - Drug testing
KW - High throughput
KW - Microspots
KW - Paper chip
UR - http://www.scopus.com/inward/record.url?scp=85137007353&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85137007353&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85137007353
T3 - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 1373
EP - 1374
BT - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Y2 - 10 October 2021 through 14 October 2021
ER -