CRYOPRESERVATION OF 3D TUMOR MODELS IN A PAPER PLATFORM

Bisan Samara, Muhammedin Deliorman, Pavithra Sukumar, Mohammad A. Qasaimeh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The ability to investigate three dimensional (3D) tumor models within their microenvironment offers great potential for understanding fundamental mechanisms governing tumor responses to drug treatments. It also provides opportunities to develop a number of emerging therapeutic applications. Selectively growing cell aggregates on predefined microspots is one of the key requirements when forming 3D tumor models for undertaking such studies. In our work, we engineered highly localized hydrophilic microspots on a paper substrate for high throughput 3D cell aggregation. Building on our previous work, we also efficiently cryopreserved the formed 3D tumor models and showed, after thaw, the compatibility of the paper platform for on-demand drug testing on the tumor models.

Original languageEnglish (US)
Title of host publicationMicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1373-1374
Number of pages2
ISBN (Electronic)9781733419031
StatePublished - 2021
Event25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 - Palm Springs, Virtual, United States
Duration: Oct 10 2021Oct 14 2021

Publication series

NameMicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Country/TerritoryUnited States
CityPalm Springs, Virtual
Period10/10/2110/14/21

Keywords

  • 3D tumor models
  • Cryopreservation
  • Drug testing
  • High throughput
  • Microspots
  • Paper chip

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)

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