Crystal structure of putrescine diphosphate: A model system for amine‐nucleic acid interactions

Nancy H. Woo, Nadrian C. Seeman, Alexander Rich

Research output: Contribution to journalArticle


The three‐dimensional structure of putrescine diphosphate has been solved by x‐ray diffraction analysis. The structure reveals the detailed interaction between the amino groups of putrescine and the phosphate residues in which hydrogen bonding and electrostatic forces play a predominant role. The structure serves as a useful model for understanding the interaction of amines with nucleic acids both in a sequence‐specific and non‐sequence‐specific fashion. In particular, a model is proposed for the interaction of the E‐amino group of lysine with regions of DNA containing adenine–thymine sequences.

Original languageEnglish (US)
Pages (from-to)539-552
Number of pages14
Issue number3
StatePublished - Mar 1979


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Biomaterials
  • Organic Chemistry

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