Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity

Debabrata Maity; Yujeong Oh; Lothar Gremer; Wolfgang Hoyer; Mazin Magzoub; Andrew D. Hamilton

doi:10.1002/chem.202201698

Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity

Debabrata Maity, Yujeong Oh, Lothar Gremer, Wolfgang Hoyer, Mazin Magzoub, Andrew D. Hamilton

Research output: Contribution to journal › Article › peer-review

Abstract

Invited for the cover of this issue is the group of Prof. Hamilton at New York University. The image depicts how cucurbit[7]uril inhibits islet amyloid polypeptide self-assembly that rescues rat insulinoma cells (a pancreatic β-cell model) from assembly-associated cytotoxicity. Read the full text of the article at 10.1002/chem.202200456.

Original language	English (US)
Pages (from-to)	e202201698
Journal	Chemistry (Weinheim an der Bergstrasse, Germany)
Volume	28
Issue number	38
DOIs	https://doi.org/10.1002/chem.202201698
State	Published - Jul 6 2022

ASJC Scopus subject areas

General Chemistry
Catalysis
Organic Chemistry

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AU - Magzoub, Mazin

AU - Hamilton, Andrew D.

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Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity

Abstract

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