Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity

Debabrata Maity, Yujeong Oh, Lothar Gremer, Wolfgang Hoyer, Mazin Magzoub, Andrew Hamilton

Research output: Contribution to journalArticlepeer-review

Abstract

Invited for the cover of this issue is the group of Prof. Hamilton at New York University. The image depicts how cucurbit[7]uril inhibits islet amyloid polypeptide self-assembly that rescues rat insulinoma cells (a pancreatic β-cell model) from assembly-associated cytotoxicity. Read the full text of the article at 10.1002/chem.202200456.

Original languageEnglish (US)
Pages (from-to)e202201698
JournalChemistry (Weinheim an der Bergstrasse, Germany)
Volume28
Issue number38
DOIs
StatePublished - Jul 6 2022

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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