Cytotoxicity and adhesion evaluation of nanothickness Ca/P-based bioceramics coated titanium

C. M. Ramirez, P. G. Coelho, J. M. Granjeiro

Research output: Contribution to journalArticlepeer-review


Incorporation of bioceramics on the surface of dental implants has been utilized in an attempt to increase biological response of bone to materials. This paper reports the in vitro biological evaluation of Ca/P-based nanothickness bioceramic coated alumina-blasted/acid-etched titanium implants (AB/AE nanotite implant) and compare its performance to the untreated and uncoated implants, Ca/P-based nanothickness bioceramic coated untreated implants (untreated nanotite implant), alumina-blasted/acid-etched titanium implants (AB/AE implant) and hydroxyapatite plasma-sprayed implants (PSHA Implant). Balb/c 3T3 fibroblasts were used to asses the cytocompatibility of implant materials according to ISO-10993-5 protocols. Osteoblasts from Balb/c femurs seeded onto different implant surfaces showed the effect of surface topography and chemistry on cell adhesion. The results showed that all implants were not cytotoxic and that PSHA and AB/AE nanotite implants favored osteoblasts adhesion.

Original languageEnglish (US)
Pages (from-to)319-322
Number of pages4
JournalKey Engineering Materials
StatePublished - 2009


  • Adhesion
  • Bioceramics coated titanium
  • Coated titanium
  • Cytotoxicity

ASJC Scopus subject areas

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering


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