Abstract
There is compelling evidence for the cancer chemopreventive effects of vitamin E and related compounds. Of all the vitamin E derivatives that have been investigated to date, vitamin E acid succinate is the most effective anti-cancer agent. This report describes the preparation and testing of liposomal formulation of mono α-tocopheryl ester of succinic acid (α-TOS) for cytotoxicity against hamster cheek pouch carcinoma cell line (HCPC-1). Small unilamellar vesicles (SUV) of phosphatidylcholine incorporating 70 μM α-TOS were superior to α-TOS alone or SUV without incorporated α-TOS, as inducers of apoptosis in HCPC-1 cells. Liposomal α-TOS perturbed the lipid structure in cells, promoted apoptosis, and decreased cell viability. The mechanism of action of α-TOS appears to involve membrane damage and induction of ceramide mediated apoptosis.
Original language | English (US) |
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Pages (from-to) | 281-291 |
Number of pages | 11 |
Journal | Cancer Letters |
Volume | 239 |
Issue number | 2 |
DOIs | |
State | Published - Aug 8 2006 |
Keywords
- Apoptosis
- Cancer therapy
- Ceramide
- Ganglioside GD3
- Vitamin E succinate
ASJC Scopus subject areas
- Oncology
- Cancer Research