Declarative Memory System: Anatomy

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary


In 1957, the groundbreaking report of Scoville and Milner showed that bilateral damage to the medial temporal lobes resulted in a permanent loss of fact and event memory (declarative memory), while sparing other cognitive functions. However the identity of the specific structure or structures within the medial temporal lobe which, when damaged, were underlying the devastating memory deficit were yet to be identified. This article describes the series of systematic lesion studies and neuroanatomical studies that cumulatively led to our current understanding of the key medial temporal lobe structures important for declarative memory.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Number of pages10
ISBN (Print)9780080450469
StatePublished - 2009


  • Amygdala
  • Delayed nonmatching to sample task
  • Entorhinal cortex
  • Episodic memory
  • Hippocampal formation
  • Hippocampus
  • Macaque monkey
  • Medial temporal lobe
  • Parahippocampal cortex
  • Patient H.M
  • Perirhinal cortex

ASJC Scopus subject areas

  • General Neuroscience


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