Deconstructing Immune Microenvironments of Lymphoid Tissues for Reverse Engineering

Ini Isabée Witzel, Rasha Nasser, Anna Garcia-Sabaté, Jiranuwat Sapudom, Chao Ma, Weiqiang Chen, Jeremy C.M. Teo

Research output: Contribution to journalReview articlepeer-review


The immune microenvironment presents a diverse panel of cues that impacts immune cell migration, organization, differentiation, and the immune response. Uniquely, both the liquid and solid phases of every specific immune niche within the body play an important role in defining cellular functions in immunity at that particular location. The in vivo immune microenvironment consists of biomechanical and biochemical signals including their gradients, surface topography, dimensionality, modes of ligand presentation, and cell–cell interactions, and the ability to recreate these immune biointerfaces in vitro can provide valuable insights into the immune system. This manuscript reviews the critical roles played by different immune cells and surveys the current progress of model systems for reverse engineering of immune microenvironments with a focus on lymphoid tissues.

Original languageEnglish (US)
Article number1801126
JournalAdvanced Healthcare Materials
Issue number4
StatePublished - Feb 21 2019


  • biomaterials
  • immune microenvironments
  • mechanobiology
  • microfluidics

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science


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