@article{13406bf33123421fbfe8aa3c77533e51,
title = "Decoupled maternal and zygotic genetic effects shape the evolution of development",
abstract = "Evolutionary transitions from indirect to direct development involve changes in both maternal and zygotic genetic factors, with distinctive population-genetic implications, but empirical data on the genetics of such transitions are lacking. The polychaete Streblospio benedicti provides an opportunity to dissect a major transition in developmental mode using forward genetics. Females in this species produce either small eggs that develop into planktonic larvae or large eggs that develop into benthic juveniles. We identify large-effect loci that act maternally to influence larval size and independent, unlinked large-effect loci that act zygotically to affect discrete aspects of larval morphology. The likely fitness of zygotic alleles depends on their maternal background, creating a positive frequency-dependence that may homogenize local populations. Developmental and population genetics interact to shape larval evolution.",
author = "Christina Zakas and Deutscher, {Jennifer M.} and Kay, {Alex D.} and Rockman, {Matthew V.}",
note = "Funding Information: We thank D Tandon, I Ukegbu, R Freih, C Fayyazi, and L Jessell for laboratory assistance with maintenance and crossing of the animals, and L Noble, M Bernstein, J Yuen for helpful discussions of the manuscript. We also thank L Noble for valuable help with genome assembly and image analysis. We thank B Pernet for collecting the Long Beach worms. This research is funded by the Zegar Family Foundation, NSF grant IOS-1350926 to MVR, NIH grant GM108396-02 to CZ, and an NYU Biology Master{\textquoteright}s Research Grant to ADK. Funding Information: We thank D Tandon, I Ukegbu, R Freih, C Fayyazi, and L Jessell for laboratory assistance with maintenance and crossing of the animals, and L Noble, M Bernstein, J Yuen for helpful discussions of the manuscript. We also thank L Noble for valuable help with genome assembly and image analysis. We thank B Pernet for collecting the Long Beach worms. This research is funded by the Zegar Family Foundation, NSF grant IOS-1350926 to MVR, NIH grant GM108396-02 to CZ, and an NYU Biology Master{\textquoteright}s Research Grant to ADK.Funder Grant reference number Author National Science Foundation IOS-1350926 Matthew V Rockman National Institutes of Health GM108396 Christina Zakas Zegar Family Foundation Matthew V Rockman New York University Biology Master{\textquoteright}s Research Grant Alex D Kay ssThe funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Publisher Copyright: {\textcopyright} Zakas et al.",
year = "2018",
month = sep,
doi = "10.7554/eLife.37143",
language = "English (US)",
volume = "7",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",
}