Decreased hippocampal metabolism in high-amyloid mild cognitive impairment

Bernard J. Hanseeuw, Aaron P. Schultz, Rebecca A. Betensky, Reisa A. Sperling, Keith A. Johnson

Research output: Contribution to journalArticlepeer-review


Introduction Hippocampal volume (HV), cortical metabolism, and thickness are decreased in mild cognitive impairment (MCI). Hippocampal metabolism (HM) studies comparing MCI and clinically normal (CN) elderly gave inconsistent results. As hippocampus is a key region in Alzheimer's disease, we hypothesized that HM is specifically decreased in high-amyloid MCI. Methods Overall, 250 CN and 45 MCI underwent three-dimensional magnetic resonance imaging, fludeoxyglucose-positron emission tomography, and fluorodeoxyglucose-positron emission tomography (PET), and Pittsburgh Compound B (PiB) PET. We investigated the interaction between clinical and amyloid status on HM, HV, cortical metabolism, and thickness using linear models, covarying age, gender, and education. Analyses were conducted with and without correction for multiple comparisons and for partial volume effects. Results Volume-adjusted HM was decreased in high-amyloid MCI but close to normal in low-amyloid MCI and in high-amyloid CN. Both MCI groups had hippocampal atrophy, although less severe in low-amyloid MCI. High-amyloid CN and high-amyloid MCI had cortical hypometabolism. Discussion HM is decreased when both cognitive impairment and amyloid are present.

Original languageEnglish (US)
Pages (from-to)1288-1296
Number of pages9
JournalAlzheimer's and Dementia
Issue number12
StatePublished - Dec 1 2016


  • Alzheimer's disease
  • Amyloid
  • Association cortex
  • Hippocampus
  • Metabolism
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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