TY - JOUR
T1 - Decreased hippocampal metabolism in high-amyloid mild cognitive impairment
AU - Hanseeuw, Bernard J.
AU - Schultz, Aaron P.
AU - Betensky, Rebecca A.
AU - Sperling, Reisa A.
AU - Johnson, Keith A.
N1 - Funding Information:
B.J.H. received support from the Belgian American Education Foundation (BAEF, grant “Plateforme pour l'Education et le Talent”), the Saint-Luc Foundation (grant “Œuvre du Calvaire-Malte”), and the Belgian Neurological Society (BNS, RFYI 2013). R.A.S. and K.A.J. have received support from National Institutes of Health/National Institute on Aging (R01 AG046396, P01 AG036694, and P50 AG00513421), Fidelity Biosciences, Harvard NeuroDiscovery Center, and the Alzheimer's Association. R.A.B. received support from National Institutes of Health/National Institute on Aging (P01 AG036694, P50 AG00513421) and the Harvard NeuroDiscovery Center.
Publisher Copyright:
© 2016 the Alzheimer's Association
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Introduction Hippocampal volume (HV), cortical metabolism, and thickness are decreased in mild cognitive impairment (MCI). Hippocampal metabolism (HM) studies comparing MCI and clinically normal (CN) elderly gave inconsistent results. As hippocampus is a key region in Alzheimer's disease, we hypothesized that HM is specifically decreased in high-amyloid MCI. Methods Overall, 250 CN and 45 MCI underwent three-dimensional magnetic resonance imaging, fludeoxyglucose-positron emission tomography, and fluorodeoxyglucose-positron emission tomography (PET), and Pittsburgh Compound B (PiB) PET. We investigated the interaction between clinical and amyloid status on HM, HV, cortical metabolism, and thickness using linear models, covarying age, gender, and education. Analyses were conducted with and without correction for multiple comparisons and for partial volume effects. Results Volume-adjusted HM was decreased in high-amyloid MCI but close to normal in low-amyloid MCI and in high-amyloid CN. Both MCI groups had hippocampal atrophy, although less severe in low-amyloid MCI. High-amyloid CN and high-amyloid MCI had cortical hypometabolism. Discussion HM is decreased when both cognitive impairment and amyloid are present.
AB - Introduction Hippocampal volume (HV), cortical metabolism, and thickness are decreased in mild cognitive impairment (MCI). Hippocampal metabolism (HM) studies comparing MCI and clinically normal (CN) elderly gave inconsistent results. As hippocampus is a key region in Alzheimer's disease, we hypothesized that HM is specifically decreased in high-amyloid MCI. Methods Overall, 250 CN and 45 MCI underwent three-dimensional magnetic resonance imaging, fludeoxyglucose-positron emission tomography, and fluorodeoxyglucose-positron emission tomography (PET), and Pittsburgh Compound B (PiB) PET. We investigated the interaction between clinical and amyloid status on HM, HV, cortical metabolism, and thickness using linear models, covarying age, gender, and education. Analyses were conducted with and without correction for multiple comparisons and for partial volume effects. Results Volume-adjusted HM was decreased in high-amyloid MCI but close to normal in low-amyloid MCI and in high-amyloid CN. Both MCI groups had hippocampal atrophy, although less severe in low-amyloid MCI. High-amyloid CN and high-amyloid MCI had cortical hypometabolism. Discussion HM is decreased when both cognitive impairment and amyloid are present.
KW - Alzheimer's disease
KW - Amyloid
KW - Association cortex
KW - FDG-PET
KW - Hippocampus
KW - Metabolism
KW - Mild cognitive impairment
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U2 - 10.1016/j.jalz.2016.06.2357
DO - 10.1016/j.jalz.2016.06.2357
M3 - Article
C2 - 27421609
AN - SCOPUS:84994461924
SN - 1552-5260
VL - 12
SP - 1288
EP - 1296
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 12
ER -