Decreased lamina cribrosa beam thickness and pore diameter relative to distance from the central retinal vessel trunk

Bo Wang, Katie A. Lucy, Joel S. Schuman, Ian A. Sigal, Richard A. Bilonick, Larry Kagemann, Tigran Kostanyan, Chen Lu, Jonathan Liu, Ireneusz Grulkowski, James G. Fujimoto, Hiroshi Ishikawa, Gadi Wollstein

    Research output: Contribution to journalArticle

    Abstract

    PURPOSE. To investigate how the lamina cribrosa (LC) microstructure changes with distance from the central retinal vessel trunk (CRVT), and to determine how this change differs in glaucoma. METHODS. One hundred nineteen eyes (40 healthy, 29 glaucoma suspect, and 50 glaucoma) of 105 subjects were imaged using swept-source optical coherence tomography (OCT). The CRVT was manually delineated at the level of the anterior LC surface. A line was fit to the distribution of LC microstructural parameters and distance from CRVT to measure the gradient (change in LC microstructure per distance from the CRVT) and intercept (LC microstructure near the CRVT). A linear mixed-effects model was used to determine the effect of diagnosis on the gradient and intercept of the LC microstructure with distance from the CRVT. A Kolmogorov-Smirnov test was applied to determine the difference in distribution between the diagnostic categories. RESULTS. The percent of visible LC in all scans was 26 ± 7%. Beam thickness and pore diameter decreased with distance from the CRVT. Glaucoma eyes had a larger decrease in beam thickness (_1.132 ± 0.503 μm, P = 0.028) and pore diameter (_0.913 ± 0.259 μm, P = 0.001) compared with healthy controls per 100 lm from the CRVT. Glaucoma eyes showed increased variability in both beam thickness and pore diameter relative to the distance from the CRVT compared with healthy eyes (P < 0.05). CONCLUSIONS. These findings results demonstrate the importance of considering the anatomical location of CRVT in the assessment of the LC, as there is a relationship between the distance from the CRVT and the LC microstructure, which differs between healthy and glaucoma eyes.

    Original languageEnglish (US)
    Pages (from-to)3088-3092
    Number of pages5
    JournalInvestigative Ophthalmology and Visual Science
    Volume57
    Issue number7
    DOIs
    StatePublished - Jun 2016

    Keywords

    • Blood vessel
    • Glaucoma
    • Optical coherence tomography

    ASJC Scopus subject areas

    • Ophthalmology
    • Sensory Systems
    • Cellular and Molecular Neuroscience

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    Wang, B., Lucy, K. A., Schuman, J. S., Sigal, I. A., Bilonick, R. A., Kagemann, L., Kostanyan, T., Lu, C., Liu, J., Grulkowski, I., Fujimoto, J. G., Ishikawa, H., & Wollstein, G. (2016). Decreased lamina cribrosa beam thickness and pore diameter relative to distance from the central retinal vessel trunk. Investigative Ophthalmology and Visual Science, 57(7), 3088-3092. https://doi.org/10.1167/iovs.15-19010