TY - JOUR
T1 - Deleterious Effects of Higher Body Mass Index on Subjective and Objective Measures of Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors
AU - Petrovchich, Iva
AU - Kober, Kord M.
AU - Wagner, L.
AU - Paul, Steven M.
AU - Abrams, Gary
AU - Chesney, Margaret A.
AU - Topp, Kimberly
AU - Smoot, B.
AU - Schumacher, Mark
AU - Conley, Yvette P.
AU - Hammer, Marilyn
AU - Levine, J. D.
AU - Miaskowski, Christine
N1 - Funding Information:
This study was funded by the National Cancer Institute (NCI, CA151692 ) and the American Cancer Society (ACS, IRG-97–150-13). Dr. Miaskowski is supported by a grant from the ACS and NCI (CA168960). This project was supported by the National Center for Advancing Translational Sciences, National Institutes of Health , through UCSF - CTSI Grant Number UL1 TR000004 . Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. Recruitment was facilitated by Dr. Susan Love Research Foundation's Army of Women ® Program.
Funding Information:
This study was funded by the National Cancer Institute (NCI, CA151692) and the American Cancer Society (ACS, IRG-97–150-13). Dr. Miaskowski is supported by a grant from the ACS and NCI (CA168960). This project was supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through UCSF-CTSI Grant Number UL1 TR000004. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. Recruitment was facilitated by Dr. Susan Love Research Foundation's Army of Women® Program.
Publisher Copyright:
© 2019 American Academy of Hospice and Palliative Medicine
PY - 2019/8
Y1 - 2019/8
N2 - Context: Recent, albeit, limited evidence suggests that body mass index (BMI) may be a modifiable risk factor to reduce the deleterious effects of chemotherapy-induced peripheral neuropathy (CIPN) in cancer survivors. Objectives: To evaluate for differences in demographic, clinical, pain, sensation, and balance characteristics among three BMI groups. We hypothesized that as BMI increased, survivors would report higher pain intensity scores and have significant decrements in measures of sensation and balance. Methods: A total of 416 survivors with CIPN were evaluated using subjective and objective measures of CIPN. Survivors were divided into three BMI groups (i.e., normal weight, overweight, and obese). Differences among the BMI groups were evaluated using parametric and nonparametric statistics. Results: Of the 416 survivors, 45.4% were normal weight, 32.5% were overweight, and 22.1% were obese. Compared with the normal-weight group, survivors in the other two groups had lower functional status scores, a higher comorbidity burden, higher pain intensity scores, and higher interference scores. In addition, compared with the normal-weight group, survivors in the other two BMI groups had significantly worse balance scores. Conclusion: Our findings support the hypothesis that as BMI increased, pain sensation and balance characteristics worsened. Our findings suggest that nutritional counseling as well as exercise and weight management programs in survivors with CIPN may improve these clinically important problems.
AB - Context: Recent, albeit, limited evidence suggests that body mass index (BMI) may be a modifiable risk factor to reduce the deleterious effects of chemotherapy-induced peripheral neuropathy (CIPN) in cancer survivors. Objectives: To evaluate for differences in demographic, clinical, pain, sensation, and balance characteristics among three BMI groups. We hypothesized that as BMI increased, survivors would report higher pain intensity scores and have significant decrements in measures of sensation and balance. Methods: A total of 416 survivors with CIPN were evaluated using subjective and objective measures of CIPN. Survivors were divided into three BMI groups (i.e., normal weight, overweight, and obese). Differences among the BMI groups were evaluated using parametric and nonparametric statistics. Results: Of the 416 survivors, 45.4% were normal weight, 32.5% were overweight, and 22.1% were obese. Compared with the normal-weight group, survivors in the other two groups had lower functional status scores, a higher comorbidity burden, higher pain intensity scores, and higher interference scores. In addition, compared with the normal-weight group, survivors in the other two BMI groups had significantly worse balance scores. Conclusion: Our findings support the hypothesis that as BMI increased, pain sensation and balance characteristics worsened. Our findings suggest that nutritional counseling as well as exercise and weight management programs in survivors with CIPN may improve these clinically important problems.
KW - Chemotherapy
KW - balance
KW - body mass index
KW - cancer survivor
KW - peripheral neuropathy
KW - platinum
KW - taxane
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U2 - 10.1016/j.jpainsymman.2019.04.029
DO - 10.1016/j.jpainsymman.2019.04.029
M3 - Article
C2 - 31047960
AN - SCOPUS:85066104386
SN - 0885-3924
VL - 58
SP - 252
EP - 263
JO - Journal of Pain and Symptom Management
JF - Journal of Pain and Symptom Management
IS - 2
ER -