Delivery of intact transcription factor by using self-assembled supramolecular nanoparticles

Yang Liu; Hao Wang; Ken Ichiro Kamei; Ming Yan; Kuan Ju Chen; Qinghua Yuan; Linqi Shi; Yunfeng Lu; Hsian Rong Tseng

doi:10.1002/anie.201005740

Delivery of intact transcription factor by using self-assembled supramolecular nanoparticles

Yang Liu, Hao Wang, Ken Ichiro Kamei, Ming Yan, Kuan Ju Chen, Qinghua Yuan, Linqi Shi, Yunfeng Lu, Hsian Rong Tseng

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

(Figure Presented) Special delivery: A supramolecular nanoparticle provides a facile and modular protein delivery system (see picture, TAT enables cell membrane penetration, RGD targeting, and PEG passivation) for highly efficient transduction of intact (unmodified) transcription factors (TF). Such a TF delivery approach provides a powerful method for manipulating cellular behavior.

Original language	English (US)
Pages (from-to)	3058-3062
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	13
DOIs	https://doi.org/10.1002/anie.201005740
State	Published - Mar 21 2011

Keywords

Nanoparticles
Protein delivery
Self-assembly
Supramolecular chemistry
Transcription factors

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201005740

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AU - Liu, Yang

AU - Wang, Hao

AU - Kamei, Ken Ichiro

AU - Yan, Ming

AU - Chen, Kuan Ju

AU - Yuan, Qinghua

AU - Shi, Linqi

AU - Lu, Yunfeng

AU - Tseng, Hsian Rong

PY - 2011/3/21

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AB - (Figure Presented) Special delivery: A supramolecular nanoparticle provides a facile and modular protein delivery system (see picture, TAT enables cell membrane penetration, RGD targeting, and PEG passivation) for highly efficient transduction of intact (unmodified) transcription factors (TF). Such a TF delivery approach provides a powerful method for manipulating cellular behavior.

KW - Nanoparticles

KW - Protein delivery

KW - Self-assembly

KW - Supramolecular chemistry

KW - Transcription factors

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Delivery of intact transcription factor by using self-assembled supramolecular nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

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