Dendrimers as drug carriers: Dynamics of PEGylated and methotrexate-loaded dendrimers in aqueous solution

Sanja Natali; Jovan Mijovic

doi:10.1021/ma902670q

Dendrimers as drug carriers: Dynamics of PEGylated and methotrexate-loaded dendrimers in aqueous solution

Sanja Natali, Jovan Mijovic

Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

An investigation of the dynamics of aqueous solutions of PEG, PEGylated dendrimers, methotrexate, and PEGylated and drug (methotrexate)-loaded dendrimers was carried out with broadband dielectric relaxation spectroscopy (DRS). Two dielectric dispersions were observed in all systems, and the explanation of their molecular origin was offered. The lower frequency process, characterized by an activation energy of 52.2 kJ/mol, was attributed to motions in ice. The higher frequency process is of the Cole Cole type and is assigned to bound water around PEG and methotrexate molecules. The effect of the average number of attached PEG chains and the average number of encapsulated methotrexate molecules was probed. Our results indicate that the dynamics are independent of these numbers but are a strong function of the composition of the complex. Spectral characteristics and temperature dependence of all relaxation processes are described.

Original language	English (US)
Pages (from-to)	3011-3017
Number of pages	7
Journal	Macromolecules
Volume	43
Issue number	6
DOIs	https://doi.org/10.1021/ma902670q
State	Published - 2010

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Inorganic Chemistry
Materials Chemistry

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10.1021/ma902670q

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abstract = "An investigation of the dynamics of aqueous solutions of PEG, PEGylated dendrimers, methotrexate, and PEGylated and drug (methotrexate)-loaded dendrimers was carried out with broadband dielectric relaxation spectroscopy (DRS). Two dielectric dispersions were observed in all systems, and the explanation of their molecular origin was offered. The lower frequency process, characterized by an activation energy of 52.2 kJ/mol, was attributed to motions in ice. The higher frequency process is of the Cole Cole type and is assigned to bound water around PEG and methotrexate molecules. The effect of the average number of attached PEG chains and the average number of encapsulated methotrexate molecules was probed. Our results indicate that the dynamics are independent of these numbers but are a strong function of the composition of the complex. Spectral characteristics and temperature dependence of all relaxation processes are described.",

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AB - An investigation of the dynamics of aqueous solutions of PEG, PEGylated dendrimers, methotrexate, and PEGylated and drug (methotrexate)-loaded dendrimers was carried out with broadband dielectric relaxation spectroscopy (DRS). Two dielectric dispersions were observed in all systems, and the explanation of their molecular origin was offered. The lower frequency process, characterized by an activation energy of 52.2 kJ/mol, was attributed to motions in ice. The higher frequency process is of the Cole Cole type and is assigned to bound water around PEG and methotrexate molecules. The effect of the average number of attached PEG chains and the average number of encapsulated methotrexate molecules was probed. Our results indicate that the dynamics are independent of these numbers but are a strong function of the composition of the complex. Spectral characteristics and temperature dependence of all relaxation processes are described.

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Dendrimers as drug carriers: Dynamics of PEGylated and methotrexate-loaded dendrimers in aqueous solution

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