Dental enamel: genes define biomechanics.

Rick J. Rauth; Karen S. Potter; Amanda Y.W. Ngan; Deema M. Saad; Rana Mehr; Vivian Q. Luong; Verna L. Schuetter; Vetea G. Miklus; Pei Pei Chang; Michael L. Paine; Rodrigo S. Lacruz; Malcolm L. Snead; Shane N. White

Dental enamel: genes define biomechanics.

Rick J. Rauth, Karen S. Potter, Amanda Y.W. Ngan, Deema M. Saad, Rana Mehr, Vivian Q. Luong, Verna L. Schuetter, Vetea G. Miklus, Pei Pei Chang, Michael L. Paine, Rodrigo S. Lacruz, Malcolm L. Snead, Shane N. White

Molecular Pathobiology

Research output: Contribution to journal › Review article › peer-review

Abstract

Regulated gene expression assembles an extracellular proteinaceous matrix to control biomineralization and the resultant biomechanical function of tooth enamel. The importance of the dominant enamel matrix protein, amelogenin (Amel); a minor transiently expressed protein, dentin sialoprotein (Dsp); an electrogenic sodium bicarbonate cotransporter (NBCe1); the timely removal of the proteinaceous matrix by a serine protease, Kallikrein-4 (Klk4); and the late-stage expression of Amelotin (Amtn) on enamel biomechanical function were demonstrated and measured using mouse models.

Original language	English (US)
Pages (from-to)	863-868
Number of pages	6
Journal	Journal of the California Dental Association
Volume	37
Issue number	12
State	Published - Dec 2009

ASJC Scopus subject areas

General Dentistry

Cite this

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title = "Dental enamel: genes define biomechanics.",

abstract = "Regulated gene expression assembles an extracellular proteinaceous matrix to control biomineralization and the resultant biomechanical function of tooth enamel. The importance of the dominant enamel matrix protein, amelogenin (Amel); a minor transiently expressed protein, dentin sialoprotein (Dsp); an electrogenic sodium bicarbonate cotransporter (NBCe1); the timely removal of the proteinaceous matrix by a serine protease, Kallikrein-4 (Klk4); and the late-stage expression of Amelotin (Amtn) on enamel biomechanical function were demonstrated and measured using mouse models.",

author = "Rauth, {Rick J.} and Potter, {Karen S.} and Ngan, {Amanda Y.W.} and Saad, {Deema M.} and Rana Mehr and Luong, {Vivian Q.} and Schuetter, {Verna L.} and Miklus, {Vetea G.} and Chang, {Pei Pei} and Paine, {Michael L.} and Lacruz, {Rodrigo S.} and Snead, {Malcolm L.} and White, {Shane N.}",

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language = "English (US)",

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T2 - genes define biomechanics.

AU - Rauth, Rick J.

AU - Potter, Karen S.

AU - Ngan, Amanda Y.W.

AU - Saad, Deema M.

AU - Mehr, Rana

AU - Luong, Vivian Q.

AU - Schuetter, Verna L.

AU - Miklus, Vetea G.

AU - Chang, Pei Pei

AU - Paine, Michael L.

AU - Lacruz, Rodrigo S.

AU - Snead, Malcolm L.

AU - White, Shane N.

PY - 2009/12

Y1 - 2009/12

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AB - Regulated gene expression assembles an extracellular proteinaceous matrix to control biomineralization and the resultant biomechanical function of tooth enamel. The importance of the dominant enamel matrix protein, amelogenin (Amel); a minor transiently expressed protein, dentin sialoprotein (Dsp); an electrogenic sodium bicarbonate cotransporter (NBCe1); the timely removal of the proteinaceous matrix by a serine protease, Kallikrein-4 (Klk4); and the late-stage expression of Amelotin (Amtn) on enamel biomechanical function were demonstrated and measured using mouse models.

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Dental enamel: genes define biomechanics.

Abstract

ASJC Scopus subject areas

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