Dental enamel: genes define biomechanics.

Rick J. Rauth, Karen S. Potter, Amanda Y.W. Ngan, Deema M. Saad, Rana Mehr, Vivian Q. Luong, Verna L. Schuetter, Vetea G. Miklus, Pei Pei Chang, Michael L. Paine, Rodrigo S. Lacruz, Malcolm L. Snead, Shane N. White

Research output: Contribution to journalReview articlepeer-review


Regulated gene expression assembles an extracellular proteinaceous matrix to control biomineralization and the resultant biomechanical function of tooth enamel. The importance of the dominant enamel matrix protein, amelogenin (Amel); a minor transiently expressed protein, dentin sialoprotein (Dsp); an electrogenic sodium bicarbonate cotransporter (NBCe1); the timely removal of the proteinaceous matrix by a serine protease, Kallikrein-4 (Klk4); and the late-stage expression of Amelotin (Amtn) on enamel biomechanical function were demonstrated and measured using mouse models.

Original languageEnglish (US)
Pages (from-to)863-868
Number of pages6
JournalJournal of the California Dental Association
Issue number12
StatePublished - Dec 2009

ASJC Scopus subject areas

  • General Dentistry


Dive into the research topics of 'Dental enamel: genes define biomechanics.'. Together they form a unique fingerprint.

Cite this