Dentate spikes and external control of hippocampal function

Dino Dvorak, Ain Chung, Eun Hye Park, André Antonio Fenton

Research output: Contribution to journalArticlepeer-review


Mouse hippocampus CA1 place-cell discharge typically encodes current location, but during slow gamma dominance (SGdom), when SG oscillations (30–50 Hz) dominate mid-frequency gamma oscillations (70–90 Hz) in CA1 local field potentials, CA1 discharge switches to represent distant recollected locations. We report that dentate spike type 2 (DSM) events initiated by medial entorhinal cortex II (MECII)→ dentate gyrus (DG) inputs promote SGdom and change excitation-inhibition coordinated discharge in DG, CA3, and CA1, whereas type 1 (DSL) events initiated by lateral entorhinal cortex II (LECII)→DG inputs do not. Just before SGdom, LECII-originating SG oscillations in DG and CA3-originating SG oscillations in CA1 phase and frequency synchronize at the DSM peak when discharge within DG and CA3 increases to promote excitation-inhibition cofiring within and across the DG→CA3→CA1 pathway. This optimizes discharge for the 5–10 ms DG-to-CA1 neuro-transmission that SGdom initiates. DSM properties identify extrahippocampal control of SGdom and a cortico-hippocampal mechanism that switches between memory-related modes of information processing.

Original languageEnglish (US)
Article number109497
JournalCell Reports
Issue number5
StatePublished - Aug 3 2021


  • dentate gyrus
  • dentate spike
  • gamma
  • memory
  • neural coordination
  • oscillations
  • place cells
  • recollection
  • source localization
  • spike-field coupling

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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