Design of a frequency domain instrument for simultaneous optical tomography and magnetic resonance imaging of small animals

James M. Masciotti, Shaheed Rahim, Jarrett Grover, Andreas H. Hielscher

    Research output: Chapter in Book/Report/Conference proceedingConference contribution


    We present a design for frequency domain instrument that allows for simultaneous gathering of magnetic resonance and diffuse optical tomographic imaging data. This small animal imaging system combines the high anatomical resolution of magnetic resonance imaging (MRI) with the high temporal resolution and physiological information provided by diffuse optical tomography (DOT). The DOT hardware comprises laser diodes and an intensified CCD camera, which are modulated up to 1 GHz by radio frequency (RF) signal generators. An optical imaging head is designed to fit inside the 4 cm inner diameter of a 9.4 T MRI system. Graded index fibers are used to transfer light between the optical hardware and the imaging head within the RF coil. Fiducial markers are integrated into the imaging head to allow the determination of the positions of the source and detector fibers on the MR images and to permit co-registration of MR and optical tomographic images. Detector fibers are arranged compactly and focused through a camera lens onto the photocathode of the intensified CCD camera.

    Original languageEnglish (US)
    Title of host publicationMultimodal Biomedical Imaging II
    StatePublished - 2007
    EventMultimodal Biomedical Imaging II - San Jose, CA, United States
    Duration: Jan 20 2007Jan 23 2007

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    ISSN (Print)1605-7422


    ConferenceMultimodal Biomedical Imaging II
    Country/TerritoryUnited States
    CitySan Jose, CA


    • Frequency domain
    • Multimodality
    • Optical tomography
    • Small animal imaging

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Atomic and Molecular Physics, and Optics
    • Biomaterials
    • Radiology Nuclear Medicine and imaging


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