Design of a protein surface antagonist based on α-helix mimicry: Inhibition of gp41 assembly and viral fusion

Justin T. Ernst; Olaf Kutzki; Asim K. Debnath; Shibo Jiang; Hong Lu; Andrew D. Hamilton

doi:10.1002/1521-3773(20020118)41:2<278::AID-ANIE278>3.0.CO;2-A

Design of a protein surface antagonist based on α-helix mimicry: Inhibition of gp41 assembly and viral fusion

Justin T. Ernst, Olaf Kutzki, Asim K. Debnath, Shibo Jiang, Hong Lu, Andrew D. Hamilton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Low micromolar inhibition of HIV-1 fusion into host cells has been achieved by using a small molecule antagonist for the disruption of the gp41 core that was designed by mimicry of the α-helical 4-3 hydrophobic repeat regions (see schematic representation).

Original language	English (US)
Pages (from-to)	278-281
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	41
Issue number	2
DOIs	https://doi.org/10.1002/1521-3773(20020118)41:2<278::AID-ANIE278>3.0.CO;2-A
State	Published - Jan 18 2002

Keywords

Drug design
HIV
Proteins
Proteomimetics

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/1521-3773(20020118)41:2<278::AID-ANIE278>3.0.CO;2-A

Cite this

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AU - Debnath, Asim K.

AU - Jiang, Shibo

AU - Lu, Hong

AU - Hamilton, Andrew D.

PY - 2002/1/18

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AB - Low micromolar inhibition of HIV-1 fusion into host cells has been achieved by using a small molecule antagonist for the disruption of the gp41 core that was designed by mimicry of the α-helical 4-3 hydrophobic repeat regions (see schematic representation).

KW - Drug design

KW - HIV

KW - Proteins

KW - Proteomimetics

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Design of a protein surface antagonist based on α-helix mimicry: Inhibition of gp41 assembly and viral fusion

Abstract

Keywords

ASJC Scopus subject areas

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