Low micromolar inhibition of HIV-1 fusion into host cells has been achieved by using a small molecule antagonist for the disruption of the gp41 core that was designed by mimicry of the α-helical 4-3 hydrophobic repeat regions (see schematic representation).
|Original language||English (US)|
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|State||Published - Jan 18 2002|
- Drug design
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