Design of two-phase prevalence surveys of rare disorders

P. E. Shrout, S. C. Newman

Research output: Contribution to journalArticle

Abstract

Two-phase medical surveys, in which a large sample is assessed with an inexpensive screening instrument and a subsample is selected for a more thorough diagnostic evaluation, appear to have great merit in the epidemiolgoic study of certain rare disorders. We present the optimal design of two-phase surveys when resources are fixed and when 100% of those screened positive in the first phase must be included in the second-phase evaluation. We go on to examine the relative efficiency of this two-phase design compared to a single-phase design in which all resources are used in a survey that employs the diagnostic evaluation. Given information on the accuracy of the screen and the prevalence of the disorder, the utility of the two-phase design depends on the relative cost of the screening to the diagnostic assessments.

Original languageEnglish (US)
Pages (from-to)549-555
Number of pages7
JournalBiometrics
Volume45
Issue number2
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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