Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices

Andrew B. Mahon, Paramjit S. Arora

Research output: Contribution to journalArticle

Abstract

Appropriately-placed hydrogen bond surrogates have been demonstrated to efficiently nucleate helical conformations. Herein we describe an efficient method for the synthesis of thioether-based hydrogen bond surrogate (teHBS) helices. A teHBS helix is shown to adopt a stable conformation and target its cognate protein receptor with high affinity.

Original languageEnglish (US)
Pages (from-to)1416-1418
Number of pages3
JournalChemical Communications
Volume48
Issue number10
DOIs
StatePublished - Jan 11 2012

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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