Designed 3D DNA crystals

Nadrian C. Seeman, Ruojie Sha, Jens Birktoft, Jianping Zheng, Wenyan Liu, Tong Wang, Chengde Mao

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The simplest practical route to producing precisely designed 3D macroscopic objects is to form a crystalline arrangement by self-assembly, because such a periodic array has only conceptually simple requirements: a motif that has a robust 3D structure, dominant affinity interactions between parts of the motif when it self-associates, and predictable structures for these affinity interactions. Fulfilling these three criteria to produce a 3D periodic system is not easy, but should readily be achieved with well-structured branched DNA motifs tailed by sticky ends (Zheng et al., Nature 461:74-77, 2009). Herein, a brief introduction to designed 3D DNA crystals from tensegrity triangle is presented.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages3-10
Number of pages8
DOIs
StatePublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1500
ISSN (Print)1064-3745

Keywords

  • DNA crystal
  • Self-assembly

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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