Designed cell-penetrating peptide inhibitors of amyloid-beta aggregation and cytotoxicity

Serdal Kirmizialtin, Anja Henning-Knechtel, Gennaro Esposito, Sunil Kumar, Andrew Hamilton

Research output: Contribution to journalArticlepeer-review


Henning-Knechtel et al. report that designed cell-penetrating peptides (CPPs) comprising a hydrophobic signal sequence and an amyloid-derived polycationic sequence effectively inhibit Aβ amyloidogenesis. The amyloid-derived polycationic sequences target highly conserved molecular features of amyloids, suggesting that the designed CPPs could function as general amyloid inhibitors.

Original languageEnglish (US)
Article number100014
JournalCell Reports Physical Science
Issue number2
StatePublished - Feb 26 2020


  • Alzheimer's disease
  • aggregation
  • amyloid-beta peptide
  • cell-penetrating peptides
  • drug design
  • neurodegeneration
  • oligomers
  • prion protein
  • protein engineering
  • signal sequence

ASJC Scopus subject areas

  • General Physics and Astronomy
  • General Materials Science
  • General Chemistry
  • General Energy
  • General Engineering


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