Designed molecular switches: Controlling the conformation of benzamido-diphenylacetylenes

Ian M. Jones, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review


With the goal of creating a molecular switch, the hydrogen-bonded diphenylacetylene structure has been modified such that an equilibrium now exists between two intramolecular H-bonded states. Through X-ray crystallography and 1H NMR analysis it is shown that this equilibrium can be biased in a predictable manner by modulating the relative acidity of the amide NH's.

Original languageEnglish (US)
Pages (from-to)3651-3653
Number of pages3
JournalOrganic Letters
Issue number16
StatePublished - Aug 20 2010

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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