Designing visible-light optical coherence tomography towards clinics

Xiao Shu, Lisa Beckmann, Yuanbo Wang, Ian Rubinoff, Katie Lucy, Hiroshi Ishikawa, Gadi Wollstein, Amani A. Fawzi, Joel S. Schuman, Roman V. Kuranov, Hao F. Zhang

Research output: Contribution to journalArticlepeer-review


Background: The capabilities of visible-light optical coherence tomography (vis-OCT) in noninvasive anatomical and functional retinal imaging have been demonstrated by multiple groups in both rodents and healthy human subjects. Translating laboratory prototypes to an integrated clinical-environment-friendly system is required to explore the full potential of vis-OCT in disease management. Methods: We developed and optimized a portable vis-OCT system for human retinal imaging in clinical settings. We acquired raster- and circular-scan images from both healthy and diseased human eyes. Results: The new vis-OCT provided high-quality retinal images of both subjects without any known eye diseases and patients with various retinal diseases, including retinal occlusive disease and diabetic retinopathy (DR) over a broad range of ages. Conclusions: A newly designed vis-OCT system is sufficiently optimized to be suited for routine patients' examinations in clinics. Vis-OCT has the potential to add new anatomical and functional imaging capabilities to ophthalmic clinical care.

Original languageEnglish (US)
Pages (from-to)769-781
Number of pages13
JournalQuantitative Imaging in Medicine and Surgery
Issue number5
StatePublished - 2019


  • High resolution imaging
  • Ophthalmology
  • Optical coherence tomography (OCT)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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