TY - JOUR
T1 - Destroying retroviruses from within
AU - Boeke, Jef D.
AU - Hahn, Beatrice
N1 - Funding Information:
We grarefullg acknowledge the ezsenrial support from the XIH. The Johns Hopkins Universiry financial interest in the CTVI method described terms of this arrangement have been reviewed School of Medicine Commitrre on Conflict of
PY - 1996/11
Y1 - 1996/11
N2 - One strategy for neutralizing retroviral infectivity is to induce the incorporation of lethal fusion proteins, such as capsid protein-nuclease fusions, into the virion during the normal viral assembly process. Genes encoding such antiviral fusion proteins must be nontoxic to the host, lethal to the virus, and must be efficiently delivered to, and expressed in, appropriate target cells.
AB - One strategy for neutralizing retroviral infectivity is to induce the incorporation of lethal fusion proteins, such as capsid protein-nuclease fusions, into the virion during the normal viral assembly process. Genes encoding such antiviral fusion proteins must be nontoxic to the host, lethal to the virus, and must be efficiently delivered to, and expressed in, appropriate target cells.
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U2 - 10.1016/0966-842X(96)10065-2
DO - 10.1016/0966-842X(96)10065-2
M3 - Review article
C2 - 8950810
AN - SCOPUS:0030296581
SN - 0966-842X
VL - 4
SP - 421
EP - 426
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 11
ER -