Destroying retroviruses from within

Jef D. Boeke, Beatrice Hahn

    Research output: Contribution to journalReview articlepeer-review


    One strategy for neutralizing retroviral infectivity is to induce the incorporation of lethal fusion proteins, such as capsid protein-nuclease fusions, into the virion during the normal viral assembly process. Genes encoding such antiviral fusion proteins must be nontoxic to the host, lethal to the virus, and must be efficiently delivered to, and expressed in, appropriate target cells.

    Original languageEnglish (US)
    Pages (from-to)421-426
    Number of pages6
    JournalTrends in Microbiology
    Issue number11
    StatePublished - Nov 1996

    ASJC Scopus subject areas

    • Microbiology
    • Microbiology (medical)
    • Infectious Diseases
    • Virology


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