Detecting lower extremity vascular dynamics in patients with peripheral artery disease using diffuse optical tomography

Michael A. Khalil, Hyun Keol K. Kim, In Kyong Kim, Rajeev Dayal, Andreas H. Hielscher

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Peripheral Artery Disease (PAD) affects over 10 million Americans and is associated with significant morbidity and mortality. While in many cases the ankle-brachial index (ABI) can be used for diagnosing the disease, this parameter is not dependable in the diabetic and elderly population. These populations tend to have calcified arteries, which leads to elevated ABI values. Dynamic optical tomography (DDOT) promises to overcome the limitations of the current diagnostic techniques and has the potential to initiate a paradigm shift in the diagnosis of vascular disease. We have performed initial pilot studies involving 5 PAD patients and 3 healthy volunteers. The time traces and tomographic reconstruction obtained from measurements on the feet show significant differences between healthy and affected vasculatures. In addition, we found that DOT is capable of identifying PAD in diabetic patients, who are misdiagnosed by the traditional ABI screening.

    Original languageEnglish (US)
    Title of host publicationOptical Tomography and Spectroscopy of Tissue IX
    DOIs
    StatePublished - 2011
    EventOptical Tomography and Spectroscopy of Tissue IX - San Francisco, CA, United States
    Duration: Jan 23 2011Jan 26 2011

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume7896
    ISSN (Print)1605-7422

    Conference

    ConferenceOptical Tomography and Spectroscopy of Tissue IX
    CountryUnited States
    CitySan Francisco, CA
    Period1/23/111/26/11

    Keywords

    • Diabetes
    • Diffuse Optical Tomography
    • Dynamic Imaging
    • Vascular Imaging

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging

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