Detection of a temporal error triggers reconsolidation of amygdala-dependent memories

Lorenzo Díaz-Mataix; Raquel Chacon Ruiz Martinez; Glenn E. Schafe; Joseph E. Ledoux; Valérie Doyère

doi:10.1016/j.cub.2013.01.053

Detection of a temporal error triggers reconsolidation of amygdala-dependent memories

Lorenzo Díaz-Mataix, Raquel Chacon Ruiz Martinez, Glenn E. Schafe, Joseph E. Ledoux, Valérie Doyère

Neural Science

Research output: Contribution to journal › Article › peer-review

Abstract

Updating memories is critical for adaptive behaviors, but the rules and mechanisms governing that process are still not well defined. During a limited time window, the reactivation of consolidated aversive memories triggers memory lability and induces a plasticity-dependent reconsolidation process in the lateral nucleus of amygdala (LA) [1-5]. However, whether new information is necessary for initiating reconsolidation is not known. Here we show that changing the temporal relationship between the conditioned stimulus (CS) and unconditioned stimulus (US) during reactivation is sufficient to trigger synaptic plasticity and reconsolidation of an aversive memory in the LA. These findings demonstrate that time is a core part of the CS-US association and that new information must be presented during reactivation in order to trigger LA-dependent reconsolidation processes. In sum, this study provides new basic knowledge about the precise rules governing memory reconsolidation of aversive memories that might be used to treat traumatic memories. Video Abstract:

Original language	English (US)
Pages (from-to)	467-472
Number of pages	6
Journal	Current Biology
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/j.cub.2013.01.053
State	Published - Mar 18 2013

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)

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title = "Detection of a temporal error triggers reconsolidation of amygdala-dependent memories",

abstract = "Updating memories is critical for adaptive behaviors, but the rules and mechanisms governing that process are still not well defined. During a limited time window, the reactivation of consolidated aversive memories triggers memory lability and induces a plasticity-dependent reconsolidation process in the lateral nucleus of amygdala (LA) [1-5]. However, whether new information is necessary for initiating reconsolidation is not known. Here we show that changing the temporal relationship between the conditioned stimulus (CS) and unconditioned stimulus (US) during reactivation is sufficient to trigger synaptic plasticity and reconsolidation of an aversive memory in the LA. These findings demonstrate that time is a core part of the CS-US association and that new information must be presented during reactivation in order to trigger LA-dependent reconsolidation processes. In sum, this study provides new basic knowledge about the precise rules governing memory reconsolidation of aversive memories that might be used to treat traumatic memories. Video Abstract:",

author = "Lorenzo D{\'i}az-Mataix and {Ruiz Martinez}, {Raquel Chacon} and Schafe, {Glenn E.} and Ledoux, {Joseph E.} and Val{\'e}rie Doy{\`e}re",

note = "Funding Information: We thank Claudia Farb for her excellent assistance with histology and Bego{\~n}a Brotons for her help in the design of the graphical abstract. R.C.R.M. was the recipient of grants CAPES #2350/09-2 and FAPESP #11/08575-7 and 12/06825-9 from the government of Brazil. V.D. was supported by Agence Nationale de la Recherche grants. V.D. and J.E.L. were recipients of collaborative grants from CNRS and the Partner University Fund. J.E.L. was the recipient of NIH grants R01 MH038774 and R01 MH46516 funding this research. ",

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AU - Doyère, Valérie

N1 - Funding Information: We thank Claudia Farb for her excellent assistance with histology and Begoña Brotons for her help in the design of the graphical abstract. R.C.R.M. was the recipient of grants CAPES #2350/09-2 and FAPESP #11/08575-7 and 12/06825-9 from the government of Brazil. V.D. was supported by Agence Nationale de la Recherche grants. V.D. and J.E.L. were recipients of collaborative grants from CNRS and the Partner University Fund. J.E.L. was the recipient of NIH grants R01 MH038774 and R01 MH46516 funding this research.

PY - 2013/3/18

Y1 - 2013/3/18

N2 - Updating memories is critical for adaptive behaviors, but the rules and mechanisms governing that process are still not well defined. During a limited time window, the reactivation of consolidated aversive memories triggers memory lability and induces a plasticity-dependent reconsolidation process in the lateral nucleus of amygdala (LA) [1-5]. However, whether new information is necessary for initiating reconsolidation is not known. Here we show that changing the temporal relationship between the conditioned stimulus (CS) and unconditioned stimulus (US) during reactivation is sufficient to trigger synaptic plasticity and reconsolidation of an aversive memory in the LA. These findings demonstrate that time is a core part of the CS-US association and that new information must be presented during reactivation in order to trigger LA-dependent reconsolidation processes. In sum, this study provides new basic knowledge about the precise rules governing memory reconsolidation of aversive memories that might be used to treat traumatic memories. Video Abstract:

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Detection of a temporal error triggers reconsolidation of amygdala-dependent memories

Abstract

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