Detection of an object in a phantom tissue using a spatial filter

Dawn V. Stephens, Frank Tittel, Lihong Wang, Andreas Hielscher, Steve Jacques

    Research output: Contribution to journalConference articlepeer-review

    Abstract

    We report the detection of an object inside a phantom tissue using a spatial filter and a 5 mW He-Ne Laser. The phantom tissue is composed of 8% scattering Polystyrene spheres (particle size 579 nm) and is diluted to different concentrations in water. The solution is placed inside of a cuvette of length 5 cm and width 5 cm. The spatial filter, composed of a 4 cm plano-convex lens and a 10 urn pinhole, is able to extract ballistic and quasi-ballistic photons from the transmitted light. A photomultiplier tube is used for detection, and a lock-in amplifier is used to reduce the amount of noise in the signal. We are able to detect the object in a phantom tissue of 20 mean free paths [mfp) (concentration .016%) with a contrast of 99.0%. The contrast in a tissue with 30 mfp (concentration .024%) is 22.7%.

    Original languageEnglish (US)
    Pages (from-to)200-208
    Number of pages9
    JournalProceedings of SPIE - The International Society for Optical Engineering
    Volume2135
    DOIs
    StatePublished - May 19 1994
    EventAdvances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases 1994 - Los Angeles, United States
    Duration: Jan 23 1994Jan 29 1994

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Computer Science Applications
    • Applied Mathematics
    • Electrical and Electronic Engineering

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