Detection of zinc ions by differential circularly polarized fluorescence excitation

Zhaohua Dai, Gloria Proni, Danny Mancheno, Sasan Karimi, Nina Berova, James W. Canary

Research output: Contribution to journalArticle

Abstract

A new chiroptical spectroscopic approach, differential circularly polarized fluorescence excitation (CPE), can be used to provide a selective method for detecting the presence of zinc ions. The approach utilizes the same instrumentation as fluorescence-detected circular dichroism and provides strong contrast in metal detection due to response to both chelation-enhanced fluorescence and circular dichroism upon metal ion binding. The observed contrast is therefore better than either of the parent spectroscopic detection methods. CPE also provides a strategy to reduce interference from background such as protein-based tryptophan fluorescence.

Original languageEnglish (US)
Pages (from-to)11760-11761
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number38
DOIs
StatePublished - Sep 29 2004

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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