Determinants of p, p'-Dichlorodiphenyldichloroethane (DDE) Concentration in Adipose Tissue in Women from Five European Cities

M. Inmaculada Sanz-gallardo; Eliseo Guallar; José M. Martín-moreno; Pieter Van 'T Veer; Frans J. Kok; Matthew P. Longnecker; J. J. Strain; Blaise C. Martin; Alwine F.M. Kardinaal; Joaquín Fernández-Crehuet; Michael Thamm; Lenore Kohlmeier

doi:10.1080/00039899909602486

Determinants of p, p'-Dichlorodiphenyldichloroethane (DDE) Concentration in Adipose Tissue in Women from Five European Cities

M. Inmaculada Sanz-gallardo, Eliseo Guallar, José M. Martín-moreno, Pieter Van 'T Veer, Frans J. Kok, Matthew P. Longnecker, J. J. Strain, Blaise C. Martin, Alwine F.M. Kardinaal, Joaquín Fernández-Crehuet, Michael Thamm, Lenore Kohlmeier

Global Public Health

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Abstract

To identify the determinants of p, p'-dichlorodiphenyldichloroethane (p, p'-DDE) in adipose tissue in subjects who participated in a cross-sectional study, we analyzed fatty acids, antioxidants, and p, p'-DDE in aspirates of adipose tissue of 328 postmenopausal women from 5 European countries. The overall mean of p, p'-DDE concentration was 1.66 μg/g of fatty acids (95% confidence interval = 1.46, 1.88). In a multiple-regression analysis, the main predictors of log₁₀(p, p'-DDE) were center of recruitment (p <.0001), adipose arachidic acid (p =.001), and adipose retinol (p =.04). These factors explained 14.9% of the overall variability of log₁₀(p, p'-DDE). In our subjects, adipose tissue p, p'-DDE concentrations were only weakly related with biomarkers reflecting intake of fish and other foods. This result is consistent with the notion that p, p'-DDE exists in different foods and, given the widespread contamination of the food chain, is relatively evenly distributed among foods.

Original language	English (US)
Pages (from-to)	277-283
Number of pages	7
Journal	Archives of Environmental Health
Volume	54
Issue number	4
DOIs	https://doi.org/10.1080/00039899909602486
State	Published - 1999

ASJC Scopus subject areas

Environmental Chemistry
General Environmental Science
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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10.1080/00039899909602486

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Sanz-gallardo, M. I., Guallar, E., Martín-moreno, J. M., Van 'T Veer, P., Kok, F. J., Longnecker, M. P., Strain, J. J., Martin, B. C., Kardinaal, A. F. M., Fernández-Crehuet, J., Thamm, M., & Kohlmeier, L. (1999). Determinants of p, p'-Dichlorodiphenyldichloroethane (DDE) Concentration in Adipose Tissue in Women from Five European Cities. Archives of Environmental Health, 54(4), 277-283. https://doi.org/10.1080/00039899909602486

Sanz-gallardo, MI, Guallar, E, Martín-moreno, JM, Van 'T Veer, P, Kok, FJ, Longnecker, MP, Strain, JJ, Martin, BC, Kardinaal, AFM, Fernández-Crehuet, J, Thamm, M & Kohlmeier, L 1999, 'Determinants of p, p'-Dichlorodiphenyldichloroethane (DDE) Concentration in Adipose Tissue in Women from Five European Cities', Archives of Environmental Health, vol. 54, no. 4, pp. 277-283. https://doi.org/10.1080/00039899909602486

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abstract = "To identify the determinants of p, p'-dichlorodiphenyldichloroethane (p, p'-DDE) in adipose tissue in subjects who participated in a cross-sectional study, we analyzed fatty acids, antioxidants, and p, p'-DDE in aspirates of adipose tissue of 328 postmenopausal women from 5 European countries. The overall mean of p, p'-DDE concentration was 1.66 μg/g of fatty acids (95% confidence interval = 1.46, 1.88). In a multiple-regression analysis, the main predictors of log10(p, p'-DDE) were center of recruitment (p <.0001), adipose arachidic acid (p =.001), and adipose retinol (p =.04). These factors explained 14.9% of the overall variability of log10(p, p'-DDE). In our subjects, adipose tissue p, p'-DDE concentrations were only weakly related with biomarkers reflecting intake of fish and other foods. This result is consistent with the notion that p, p'-DDE exists in different foods and, given the widespread contamination of the food chain, is relatively evenly distributed among foods.",

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AU - Sanz-gallardo, M. Inmaculada

AU - Guallar, Eliseo

AU - Martín-moreno, José M.

AU - Van 'T Veer, Pieter

AU - Kok, Frans J.

AU - Longnecker, Matthew P.

AU - Strain, J. J.

AU - Martin, Blaise C.

AU - Kardinaal, Alwine F.M.

AU - Fernández-Crehuet, Joaquín

AU - Thamm, Michael

AU - Kohlmeier, Lenore

PY - 1999

Y1 - 1999

N2 - To identify the determinants of p, p'-dichlorodiphenyldichloroethane (p, p'-DDE) in adipose tissue in subjects who participated in a cross-sectional study, we analyzed fatty acids, antioxidants, and p, p'-DDE in aspirates of adipose tissue of 328 postmenopausal women from 5 European countries. The overall mean of p, p'-DDE concentration was 1.66 μg/g of fatty acids (95% confidence interval = 1.46, 1.88). In a multiple-regression analysis, the main predictors of log10(p, p'-DDE) were center of recruitment (p <.0001), adipose arachidic acid (p =.001), and adipose retinol (p =.04). These factors explained 14.9% of the overall variability of log10(p, p'-DDE). In our subjects, adipose tissue p, p'-DDE concentrations were only weakly related with biomarkers reflecting intake of fish and other foods. This result is consistent with the notion that p, p'-DDE exists in different foods and, given the widespread contamination of the food chain, is relatively evenly distributed among foods.

AB - To identify the determinants of p, p'-dichlorodiphenyldichloroethane (p, p'-DDE) in adipose tissue in subjects who participated in a cross-sectional study, we analyzed fatty acids, antioxidants, and p, p'-DDE in aspirates of adipose tissue of 328 postmenopausal women from 5 European countries. The overall mean of p, p'-DDE concentration was 1.66 μg/g of fatty acids (95% confidence interval = 1.46, 1.88). In a multiple-regression analysis, the main predictors of log10(p, p'-DDE) were center of recruitment (p <.0001), adipose arachidic acid (p =.001), and adipose retinol (p =.04). These factors explained 14.9% of the overall variability of log10(p, p'-DDE). In our subjects, adipose tissue p, p'-DDE concentrations were only weakly related with biomarkers reflecting intake of fish and other foods. This result is consistent with the notion that p, p'-DDE exists in different foods and, given the widespread contamination of the food chain, is relatively evenly distributed among foods.

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Determinants of p, p'-Dichlorodiphenyldichloroethane (DDE) Concentration in Adipose Tissue in Women from Five European Cities

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