Determination of the blood oxygenation in the brain by time-resolved reflectance spectroscopy: contribution of vascular absorption and tissue background absorption

Hanli Liu; Andreas H. Hielscher; Bertrand Beauvoit; Li Hong Wang; Steven L. Jacques; Frank K. Tittel; Britton Chance

Determination of the blood oxygenation in the brain by time-resolved reflectance spectroscopy: contribution of vascular absorption and tissue background absorption

Hanli Liu, Andreas H. Hielscher, Bertrand Beauvoit, Li Hong Wang, Steven L. Jacques, Frank K. Tittel, Britton Chance

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The possibility of measuring the blood oxygenation in the brain with near infrared light has been studied. The goal of this study was to quantify the influence of different brain layers on brain blood oxygenation measurements. Experimental results obtained from time resolved reflectance measurements on layered tissue phantoms were compared to Monte Carlo simulations of layered models, diffusion theory, and in vivo measurements on the human head. Both the experimental results and simulations show that the absorption coefficient μ_a, which is closely related to the blood oxygenation, of deeper layers can be accessed in the time domain. Thus fitting analytical expressions found from diffusion theory only to the late part of the time resolved reflectance allows us to determine μ_a and subsequently the blood oxygenation of the deepest medium (e.g. brain tissue).

Original language	English (US)
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Publisher	Society of Photo-Optical Instrumentation Engineers
Pages	4-14
Number of pages	11
ISBN (Print)	081941431X
State	Published - 1994
Event	Biochemical Diagnostic Instrumentation - Los Angeles, CA, USA Duration: Jan 24 1994 → Jan 24 1994

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	2136
ISSN (Print)	0277-786X

Conference

Conference	Biochemical Diagnostic Instrumentation
City	Los Angeles, CA, USA
Period	1/24/94 → 1/24/94

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

Cite this

Liu, H., Hielscher, A. H., Beauvoit, B., Wang, L. H., Jacques, S. L., Tittel, F. K., & Chance, B. (1994). Determination of the blood oxygenation in the brain by time-resolved reflectance spectroscopy: contribution of vascular absorption and tissue background absorption. In Proceedings of SPIE - The International Society for Optical Engineering (pp. 4-14). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 2136). Society of Photo-Optical Instrumentation Engineers.

Determination of the blood oxygenation in the brain by time-resolved reflectance spectroscopy : contribution of vascular absorption and tissue background absorption. / Liu, Hanli; Hielscher, Andreas H.; Beauvoit, Bertrand et al.

Proceedings of SPIE - The International Society for Optical Engineering. Society of Photo-Optical Instrumentation Engineers, 1994. p. 4-14 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 2136).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Liu, H, Hielscher, AH, Beauvoit, B, Wang, LH, Jacques, SL, Tittel, FK & Chance, B 1994, Determination of the blood oxygenation in the brain by time-resolved reflectance spectroscopy: contribution of vascular absorption and tissue background absorption. in Proceedings of SPIE - The International Society for Optical Engineering. Proceedings of SPIE - The International Society for Optical Engineering, vol. 2136, Society of Photo-Optical Instrumentation Engineers, pp. 4-14, Biochemical Diagnostic Instrumentation, Los Angeles, CA, USA, 1/24/94.

Liu H, Hielscher AH, Beauvoit B, Wang LH, Jacques SL, Tittel FK et al. Determination of the blood oxygenation in the brain by time-resolved reflectance spectroscopy: contribution of vascular absorption and tissue background absorption. In Proceedings of SPIE - The International Society for Optical Engineering. Society of Photo-Optical Instrumentation Engineers. 1994. p. 4-14. (Proceedings of SPIE - The International Society for Optical Engineering).

Liu, Hanli ; Hielscher, Andreas H. ; Beauvoit, Bertrand et al. / Determination of the blood oxygenation in the brain by time-resolved reflectance spectroscopy : contribution of vascular absorption and tissue background absorption. Proceedings of SPIE - The International Society for Optical Engineering. Society of Photo-Optical Instrumentation Engineers, 1994. pp. 4-14 (Proceedings of SPIE - The International Society for Optical Engineering).

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abstract = "The possibility of measuring the blood oxygenation in the brain with near infrared light has been studied. The goal of this study was to quantify the influence of different brain layers on brain blood oxygenation measurements. Experimental results obtained from time resolved reflectance measurements on layered tissue phantoms were compared to Monte Carlo simulations of layered models, diffusion theory, and in vivo measurements on the human head. Both the experimental results and simulations show that the absorption coefficient μ a, which is closely related to the blood oxygenation, of deeper layers can be accessed in the time domain. Thus fitting analytical expressions found from diffusion theory only to the late part of the time resolved reflectance allows us to determine μa and subsequently the blood oxygenation of the deepest medium (e.g. brain tissue).",

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AB - The possibility of measuring the blood oxygenation in the brain with near infrared light has been studied. The goal of this study was to quantify the influence of different brain layers on brain blood oxygenation measurements. Experimental results obtained from time resolved reflectance measurements on layered tissue phantoms were compared to Monte Carlo simulations of layered models, diffusion theory, and in vivo measurements on the human head. Both the experimental results and simulations show that the absorption coefficient μ a, which is closely related to the blood oxygenation, of deeper layers can be accessed in the time domain. Thus fitting analytical expressions found from diffusion theory only to the late part of the time resolved reflectance allows us to determine μa and subsequently the blood oxygenation of the deepest medium (e.g. brain tissue).

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Determination of the blood oxygenation in the brain by time-resolved reflectance spectroscopy: contribution of vascular absorption and tissue background absorption

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