Determination of the blood oxygenation in the brain by time-resolved reflectance spectroscopy: contribution of vascular absorption and tissue background absorption

Hanli Liu, Andreas H. Hielscher, Bertrand Beauvoit, Li Hong Wang, Steven L. Jacques, Frank K. Tittel, Britton Chance

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    The possibility of measuring the blood oxygenation in the brain with near infrared light has been studied. The goal of this study was to quantify the influence of different brain layers on brain blood oxygenation measurements. Experimental results obtained from time resolved reflectance measurements on layered tissue phantoms were compared to Monte Carlo simulations of layered models, diffusion theory, and in vivo measurements on the human head. Both the experimental results and simulations show that the absorption coefficient μ a, which is closely related to the blood oxygenation, of deeper layers can be accessed in the time domain. Thus fitting analytical expressions found from diffusion theory only to the late part of the time resolved reflectance allows us to determine μa and subsequently the blood oxygenation of the deepest medium (e.g. brain tissue).

    Original languageEnglish (US)
    Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
    PublisherSociety of Photo-Optical Instrumentation Engineers
    Pages4-14
    Number of pages11
    ISBN (Print)081941431X
    StatePublished - 1994
    EventBiochemical Diagnostic Instrumentation - Los Angeles, CA, USA
    Duration: Jan 24 1994Jan 24 1994

    Publication series

    NameProceedings of SPIE - The International Society for Optical Engineering
    Volume2136
    ISSN (Print)0277-786X

    Conference

    ConferenceBiochemical Diagnostic Instrumentation
    CityLos Angeles, CA, USA
    Period1/24/941/24/94

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Computer Science Applications
    • Applied Mathematics
    • Electrical and Electronic Engineering

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