Determining the location of the fovea centralis via en-face slo and cross-sectional oct imaging in patients without retinal pathology

Archana A. Nair, Rebecca Liebenthal, Shefali Sood, Grant L. Hom, Marc E. Ohlhausen, Thais F. Conti, Carolina C.S. Valentim, Hiroshi Ishikawa, Gadi Wollstein, Joel S. Schuman, Rishi P. Singh, Yasha S. Modi

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Purpose: The purpose was to establish the position of the fovea centralis to the optic nerve via en-face, near-infrared spectral domain optical coherence tomography (NIR-OCT) in healthy patients. This may shed light on physiological variability and be used for studying subtle cases of foveal ectopia in macular pathology and after retinal detach-ment. Methods: SD-OCT data of 890 healthy eyes were retrospectively analyzed. Exclusion criteria included axial myopia causing tilting of the optic disc, peripapillary atrophy >1/3 the width of the disc, macular images excluding greater than half of the optic disc, and patients unable to maintain vertical head positioning. Two independent reviewers measured the horizontal and vertical distance from the fovea to the optic disc center and optic disc diameter via cross-sectional and en-face scanning laser ophthalmoloscopy OCT imaging. Results: 890 eyes were included in the study. The right and left eyes differed in the horizontal distance from the fovea to the disc center (4359 vs. 4248 μm, P < 0.001) and vertical distance from the fovea to the disc center (464 μm vs. 647, P < 0.001). This corresponded to a smaller angle between the right and left eyes (6.07° vs. 8.67°, P < 0.001). Older age was associated with a larger horizontal (P = 0.008) and vertical distance (0.025). These differences persisted after correcting for axial length in the 487 patients with axial-length data. Conclusions: This study compares the position of the fovea centralis among individuals without macular pathology on a micron level basis. The significant variability between right and left eyes indicates that contralateral eye evaluation cannot be reliably used. Rather, true foveal ectopia requires assessments of preoperative and postoperative NIR-OCT scans. This finding is relevant to retinal detachment cases and evaluation of subtle foveal ectopia.

    Original languageEnglish (US)
    Article number25
    Pages (from-to)1-10
    Number of pages10
    JournalTranslational Vision Science and Technology
    Volume10
    Issue number2
    DOIs
    StatePublished - 2021

    Keywords

    • Fovea centralis
    • OCT
    • Retina

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Ophthalmology

    Fingerprint

    Dive into the research topics of 'Determining the location of the fovea centralis via en-face slo and cross-sectional oct imaging in patients without retinal pathology'. Together they form a unique fingerprint.

    Cite this