Developing multicomponent interventions using fractional factorial designs

Bibhas Chakraborty, Linda M. Collins, Victor J. Strecher, Susan A. Murphy

Research output: Contribution to journalArticlepeer-review


Multicomponent interventions composed of behavioral, delivery, or implementation factors in addition to medications are becoming increasingly common in health sciences. A natural experimental approach to developing and refining such multicomponent interventions is to start with a large number of potential components and screen out the least active ones. Factorial designs can be used efficiently in this endeavor. We address common criticisms and misconceptions regarding the use of factorial designs in these screening studies. We also provide an operationalization of screening studies. As an example, we consider the use of a screening study in the development of a multicomponent smoking cessation intervention. Simulation results are provided to support the discussions.

Original languageEnglish (US)
Pages (from-to)2687-2708
Number of pages22
JournalStatistics in Medicine
Issue number21
StatePublished - Sep 20 2009


  • Experimental design
  • Follow-up studies
  • Fractional factorial design
  • Multicomponent intervention
  • Screening

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability


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