@inbook{c2d3790c92c44497a0c755a72710e04e,
title = "Development and Evolution of the Ascidian Cardiogenic Mesoderm",
abstract = "The heart and other blood pumping organs are close to being universally essential in the animal kingdom. These organs present a large anatomical, morphological, and cellular diversity, which is thought to have arisen by building developmental modules on a conserved core of ancestral heart regulatory units. In this context, studies using the ascidian model system Ciona intestinalis offer a distinctive set of theoretical and experimental advantages, which we herein discuss in details. Development of the heart and related muscles in Ciona has been analyzed with a cellular to subcellular resolution unprecedented in Chordate model systems. Unique derived developmental characters of the cardiogenic mesoderm appear to be shared between Ciona and vertebrates. Notably, accumulating evidence point to an early Chordate origin of the cardiopharyngeal population of mesoderm cells that may have provided the foundation for the emergence of the second heart field in higher vertebrates.",
keywords = "Chordate, Heart, Migration, Muscle, Regulatory network, Transcription, Tunicate",
author = "Theadora Tolkin and Lionel Christiaen",
note = "Funding Information: We thank Alexandra Ketcham for the double fluorescent in situ hybridization and immunostaining showed in Fig. 4.4 C. We would also like to thank Alberto Stolfi for his thoughtful comments on the chapter. Our work is supported by Grants 10SDG4310061 from the American Heart Association, R01GM096032 from NIGMS/NIH, R01HL108643 from NHLBI/NIH, by the New York Cardiac Center, and by the New York University College of Arts and Sciences.",
year = "2012",
doi = "10.1016/B978-0-12-387786-4.00011-7",
language = "English (US)",
series = "Current Topics in Developmental Biology",
publisher = "Academic Press Inc.",
pages = "107--142",
booktitle = "Current Topics in Developmental Biology",
address = "United States",
}