Development and influence of inhibition in the lateral superior olivary nucleus

Dan H. Sanes, Eckhard Friauf

Research output: Contribution to journalArticlepeer-review


While studies of neuronal development and plasticity have focused on excitatory pathways, the inhibitory projection from the MNTB to the LSO provides a favorable model for studies of synaptic inhibition. This review covers recent studies from our laboratories indicating that inhibitory connections are quite dynamic during development. These findings suggest that there are two phases inhibitory transmission. During an initial depolarizing phase is growth and branching of pre- and postsynaptic elements in the LSO. During a second hyperpolarizing phase there is refinement of inhibitory afferent arborizations and the LSO dendrites that they innervate. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)46-58
Number of pages13
JournalHearing Research
Issue number1-2
StatePublished - Sep 2000


  • Dendrite
  • Glycine
  • Neurotransmission
  • Superior olivary complex
  • γ-Aminobutyric acid

ASJC Scopus subject areas

  • Sensory Systems


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