Development and influence of inhibition in the lateral superior olivary nucleus

Dan H. Sanes; Eckhard Friauf

doi:10.1016/S0378-5955(00)00119-2

Development and influence of inhibition in the lateral superior olivary nucleus

Dan H. Sanes, Eckhard Friauf

Neural Science

Research output: Contribution to journal › Article › peer-review

Abstract

While studies of neuronal development and plasticity have focused on excitatory pathways, the inhibitory projection from the MNTB to the LSO provides a favorable model for studies of synaptic inhibition. This review covers recent studies from our laboratories indicating that inhibitory connections are quite dynamic during development. These findings suggest that there are two phases inhibitory transmission. During an initial depolarizing phase is growth and branching of pre- and postsynaptic elements in the LSO. During a second hyperpolarizing phase there is refinement of inhibitory afferent arborizations and the LSO dendrites that they innervate. (C) 2000 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	46-58
Number of pages	13
Journal	Hearing Research
Volume	147
Issue number	1-2
DOIs	https://doi.org/10.1016/S0378-5955(00)00119-2
State	Published - Sep 2000

Keywords

Dendrite
Glycine
Neurotransmission
Superior olivary complex
γ-Aminobutyric acid

ASJC Scopus subject areas

Sensory Systems

Access to Document

10.1016/S0378-5955(00)00119-2

Cite this

@article{b57e3309ee2f4b428bab74b69a48189a,

title = "Development and influence of inhibition in the lateral superior olivary nucleus",

abstract = "While studies of neuronal development and plasticity have focused on excitatory pathways, the inhibitory projection from the MNTB to the LSO provides a favorable model for studies of synaptic inhibition. This review covers recent studies from our laboratories indicating that inhibitory connections are quite dynamic during development. These findings suggest that there are two phases inhibitory transmission. During an initial depolarizing phase is growth and branching of pre- and postsynaptic elements in the LSO. During a second hyperpolarizing phase there is refinement of inhibitory afferent arborizations and the LSO dendrites that they innervate. (C) 2000 Elsevier Science B.V.",

keywords = "Dendrite, Glycine, Neurotransmission, Superior olivary complex, γ-Aminobutyric acid",

author = "Sanes, {Dan H.} and Eckhard Friauf",

note = "Funding Information: This work was supported by NIH DC00540 (D.H.S.) and Deutsche Forschungsgemeinschaft, SFB 269 (E.F.). ",

year = "2000",

month = sep,

doi = "10.1016/S0378-5955(00)00119-2",

language = "English (US)",

volume = "147",

pages = "46--58",

journal = "Hearing Research",

issn = "0378-5955",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Development and influence of inhibition in the lateral superior olivary nucleus

AU - Sanes, Dan H.

AU - Friauf, Eckhard

N1 - Funding Information: This work was supported by NIH DC00540 (D.H.S.) and Deutsche Forschungsgemeinschaft, SFB 269 (E.F.).

PY - 2000/9

Y1 - 2000/9

N2 - While studies of neuronal development and plasticity have focused on excitatory pathways, the inhibitory projection from the MNTB to the LSO provides a favorable model for studies of synaptic inhibition. This review covers recent studies from our laboratories indicating that inhibitory connections are quite dynamic during development. These findings suggest that there are two phases inhibitory transmission. During an initial depolarizing phase is growth and branching of pre- and postsynaptic elements in the LSO. During a second hyperpolarizing phase there is refinement of inhibitory afferent arborizations and the LSO dendrites that they innervate. (C) 2000 Elsevier Science B.V.

AB - While studies of neuronal development and plasticity have focused on excitatory pathways, the inhibitory projection from the MNTB to the LSO provides a favorable model for studies of synaptic inhibition. This review covers recent studies from our laboratories indicating that inhibitory connections are quite dynamic during development. These findings suggest that there are two phases inhibitory transmission. During an initial depolarizing phase is growth and branching of pre- and postsynaptic elements in the LSO. During a second hyperpolarizing phase there is refinement of inhibitory afferent arborizations and the LSO dendrites that they innervate. (C) 2000 Elsevier Science B.V.

KW - Dendrite

KW - Glycine

KW - Neurotransmission

KW - Superior olivary complex

KW - γ-Aminobutyric acid

UR - http://www.scopus.com/inward/record.url?scp=0033842532&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033842532&partnerID=8YFLogxK

U2 - 10.1016/S0378-5955(00)00119-2

DO - 10.1016/S0378-5955(00)00119-2

M3 - Article

C2 - 10962172

AN - SCOPUS:0033842532

SN - 0378-5955

VL - 147

SP - 46

EP - 58

JO - Hearing Research

JF - Hearing Research

IS - 1-2

ER -

Development and influence of inhibition in the lateral superior olivary nucleus

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this