Development of a dynamic optical tomographic breast imaging system with digital detection techniques

Molly L. Flexman; James M. Masciotti; Michael Khalil; Alisha Ling; Rabah Al Abdi; Randall L. Barbour; Andreas H. Hielscher

doi:10.1117/12.809153

Development of a dynamic optical tomographic breast imaging system with digital detection techniques

Molly L. Flexman, James M. Masciotti, Michael Khalil, Alisha Ling, Rabah Al Abdi, Randall L. Barbour, Andreas H. Hielscher

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Breast cancer characteristics such as angiogenesis and hypoxia can be quantified by using optical tomography imaging to observe the hemodynamic response to an external stimulus. A digital near-infrared tomography system has been developed specifically for the purpose of dynamic breast imaging. It simultaneously acquires four frequency encoded wavelengths of light at 765, 808, 827, and 905nm in order to facilitate the functional imaging of oxy-and deoxy-hemoglobin, lipid concentration and water content. The system uses 32 source fibers to simultaneously illuminate both breasts. There are 128 detector fibers, 64 fibers for each breast, which deliver the detected light to silicon photo-detectors. The signal is conditioned by variable gain amplifiers and filters and is quantized by an analog to digital converter (ADC). The sampled signal is then passed on for processing using a Digital Signal Processor (DSP) prior to display on a host computer. The system can acquire 2.23 frames per second with a dynamic range of 236 dB.

Original language	English (US)
Title of host publication	Optical Tomography and Spectroscopy of Tissue VIII
Subtitle of host publication	SPIE International Symposium on Biomedical Optics Proceedings
Volume	7174
DOIs	https://doi.org/10.1117/12.809153
State	Published - 2009
Event	Optical Tomography and Spectroscopy of Tissue VIII - San Jose, CA, United States Duration: Jan 25 2009 → Jan 27 2009

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Publisher	SPIE
ISSN (Print)	1605-7422

Conference

Conference	Optical Tomography and Spectroscopy of Tissue VIII
Country/Territory	United States
City	San Jose, CA
Period	1/25/09 → 1/27/09

Keywords

Breast imaging
digital hardware.
Dynamic imaging
Optical Tomography

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.809153

Cite this

Flexman, M. L., Masciotti, J. M., Khalil, M., Ling, A., Abdi, R. A., Barbour, R. L., & Hielscher, A. H. (2009). Development of a dynamic optical tomographic breast imaging system with digital detection techniques. In Optical Tomography and Spectroscopy of Tissue VIII: SPIE International Symposium on Biomedical Optics Proceedings (Vol. 7174). (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.809153

Development of a dynamic optical tomographic breast imaging system with digital detection techniques. / Flexman, Molly L.; Masciotti, James M.; Khalil, Michael et al.
Optical Tomography and Spectroscopy of Tissue VIII: SPIE International Symposium on Biomedical Optics Proceedings. Vol. 7174 2009. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Flexman, ML, Masciotti, JM, Khalil, M, Ling, A, Abdi, RA, Barbour, RL & Hielscher, AH 2009, Development of a dynamic optical tomographic breast imaging system with digital detection techniques. in Optical Tomography and Spectroscopy of Tissue VIII: SPIE International Symposium on Biomedical Optics Proceedings. vol. 7174, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Optical Tomography and Spectroscopy of Tissue VIII, San Jose, CA, United States, 1/25/09. https://doi.org/10.1117/12.809153

Flexman ML, Masciotti JM, Khalil M, Ling A, Abdi RA, Barbour RL et al. Development of a dynamic optical tomographic breast imaging system with digital detection techniques. In Optical Tomography and Spectroscopy of Tissue VIII: SPIE International Symposium on Biomedical Optics Proceedings. Vol. 7174. 2009. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.809153

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Development of a dynamic optical tomographic breast imaging system with digital detection techniques

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

Access to Document

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