Development of a new photochromic ion channel blocker via azologization of fomocaine

Matthias Schoenberger, Arunas Damijonaitis, Zinan Zhang, Daniel Nagel, Dirk Trauner

Research output: Contribution to journalArticle

Abstract

Photochromic blockers of voltage gated ion channels are powerful tools for the control of neuronal systems with high spatial and temporal precision. We now introduce fotocaine, a new type of photochromic channel blocker based on the long-lasting anesthetic fomocaine. Fotocaine is readily taken up by neurons in brain slices and enables the optical control of action potential firing by switching between 350 and 450 nm light. It also provides an instructive example for "azologization", that is, the systematic conversion of an established drug into a photoswitchable one.

Original languageEnglish (US)
Pages (from-to)514-518
Number of pages5
JournalACS Chemical Neuroscience
Volume5
Issue number7
DOIs
StatePublished - Jul 16 2014

Keywords

  • Photopharmacology
  • action potential firing control
  • azobenzene photoswitch
  • azologization
  • fomocaine
  • local anesthetics

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Cognitive Neuroscience
  • Cell Biology

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  • Cite this

    Schoenberger, M., Damijonaitis, A., Zhang, Z., Nagel, D., & Trauner, D. (2014). Development of a new photochromic ion channel blocker via azologization of fomocaine. ACS Chemical Neuroscience, 5(7), 514-518. https://doi.org/10.1021/cn500070w