Development of a new photochromic ion channel blocker via azologization of fomocaine

Matthias Schoenberger; Arunas Damijonaitis; Zinan Zhang; Daniel Nagel; Dirk Trauner

doi:10.1021/cn500070w

Development of a new photochromic ion channel blocker via azologization of fomocaine

Matthias Schoenberger, Arunas Damijonaitis, Zinan Zhang, Daniel Nagel, Dirk Trauner

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Photochromic blockers of voltage gated ion channels are powerful tools for the control of neuronal systems with high spatial and temporal precision. We now introduce fotocaine, a new type of photochromic channel blocker based on the long-lasting anesthetic fomocaine. Fotocaine is readily taken up by neurons in brain slices and enables the optical control of action potential firing by switching between 350 and 450 nm light. It also provides an instructive example for "azologization", that is, the systematic conversion of an established drug into a photoswitchable one.

Original language	English (US)
Pages (from-to)	514-518
Number of pages	5
Journal	ACS Chemical Neuroscience
Volume	5
Issue number	7
DOIs	https://doi.org/10.1021/cn500070w
State	Published - Jul 16 2014

Keywords

Photopharmacology
action potential firing control
azobenzene photoswitch
azologization
fomocaine
local anesthetics

ASJC Scopus subject areas

Biochemistry
Physiology
Cognitive Neuroscience
Cell Biology

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10.1021/cn500070w

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AU - Trauner, Dirk

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AB - Photochromic blockers of voltage gated ion channels are powerful tools for the control of neuronal systems with high spatial and temporal precision. We now introduce fotocaine, a new type of photochromic channel blocker based on the long-lasting anesthetic fomocaine. Fotocaine is readily taken up by neurons in brain slices and enables the optical control of action potential firing by switching between 350 and 450 nm light. It also provides an instructive example for "azologization", that is, the systematic conversion of an established drug into a photoswitchable one.

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Development of a new photochromic ion channel blocker via azologization of fomocaine

Abstract

Keywords

ASJC Scopus subject areas

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