Development of a photoswitchable antagonist of NMDA receptors

Felix W.W. Hartrampf, David M. Barber, Kevin Gottschling, Philipp Leippe, Michael Hollmann, Dirk Trauner

Research output: Contribution to journalArticlepeer-review


N-methyl–Daspartate receptors (NMDARs) are vital for neurological processes such as learning, memory, and synaptic plasticity. As such, small molecules that modulate their function are of interest in the study of numerous neurological diseases. We have synthesized a small library of photoswitches that modulate NMDAR function. The most efficient photoswitch to date is based on a known ligand of the glycine binding site and shows significant subtype selectivity.

Original languageEnglish (US)
Pages (from-to)4905-4912
Number of pages8
Issue number33
StatePublished - 2017


  • Antagonist
  • Azobenzene
  • Photopharmacology
  • Photoswitch
  • glutamate receptor

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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